Nature Search

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4⁺ T cells

The transcription factor c-Maf controls IL-10 production in T cells. O’Garra and colleagues use systems and in vivo functional analysis of T cell subsets to reveal distinct context-specific roles for c-Maf.

Leona Gabryšová
Marisol Alvarez-Martinez
Anne O’Garra
Research16 Apr 2018
Nature Immunology

Volume: 19, P: 497-507
M-CSF instructs myeloid lineage fate in single haematopoietic stem cells

M-CSF, a myeloid cytokine released during infection and inflammation, instructs myeloid lineage fate in single haematopoietic stem cells by directly inducing PU.1, a known myeloid lineage master regulator; this shows that specific cytokines can act directly on haematopoietic stem cells to instruct a change of cell identity.

Noushine Mossadegh-Keller
Sandrine Sarrazin
Michael H. Sieweke
Research10 Apr 2013
Nature

Volume: 497, P: 239-243
Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo

Sieweke and colleagues show that alveolar macrophages maintain a core gene expression program even after several months in culture and reacquire full transcriptional and epigenetic identity after transplantation into the lung.

Sethuraman Subramanian
Clara Jana-Lui Busch
Michael H. Sieweke
Research24 Feb 2022
Nature Immunology

Volume: 23, P: 458-468
Publisher Correction: c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4⁺ T cells

Leona Gabryšová
Marisol Alvarez-Martinez
Anne O’Garra
Amendments and Corrections08 Feb 2019
Nature Immunology

Volume: 20, P: 374
Lifestyle shapes preclinical social and microglial deficits in an Alzheimer’s disease mouse model

Fanny Ehret
Birte Doludda
Gerd Kempermann
ResearchOpen Access12 Dec 2025
Molecular Psychiatry

P: 1-11
Eosinophils and mast cells: a lineage apart

Single-cell transcriptome analysis has identified progenitor populations with mast-cell and eosinophil potential that are distinct from the neutrophil-monocyte lineage, segregate early in hematopoietic development and can be discriminated by expression of the transcription factor GATA-1.

Sandrine Sarrazin
Michael H Sieweke
News & Views19 May 2016
Nature Immunology

Volume: 17, P: 609-611
MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth

Bruno Blanchi
Louise M Kelly
Michael H Sieweke
Research25 Sept 2003
Nature Neuroscience

Volume: 6, P: 1091-1100
Trained macrophages support hygiene hypothesis

Replacement of resident alveolar macrophages by monocyte-derived macrophages after herpesvirus infection protects against asthma.

Bérengère de Laval
Michael H Sieweke
News & Views16 Nov 2017
Nature Immunology

Volume: 18, P: 1279-1280
Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Maziar Divangahi
Peter Aaby
Mihai G. Netea
Amendments and Corrections20 May 2021
Nature Immunology

Volume: 22, P: 928
Trained immunity, tolerance, priming and differentiation: distinct immunological processes

The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects, is necessary for advancing this field of research. Here we aim to establish a common framework that describes the experimental standards for defining trained immunity.

Maziar Divangahi
Peter Aaby
Mihai G. Netea
Comments & Opinion08 Dec 2020
Nature Immunology

Volume: 22, P: 2-6

Search

Filter By:

Search

Quick links