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Showing 1–12 of 12 results
Advanced filters: Author: Michael Mannstadt Clear advanced filters

  • Hypoparathyroidism is a disease characterized by inadequately low circulating levels of parathyroid hormone resulting in low calcium levels and increased phosphate levels in the blood. In this Primer, Mannstadt et al. summarize current knowledge of the prevalence, pathophysiology, clinical presentation and management of hypoparathyroidism.

    • Michael Mannstadt
    • John P. Bilezikian
    • Dolores M. Shoback
    Reviews
    Nature Reviews Disease Primers
    Volume: 3, P: 1-21

    • Michael Mannstadt
    • John P. Bilezikian
    • Dolores M. Shoback
    Amendments and Corrections
    Nature Reviews Disease Primers
    Volume: 3, P: 1

  • Current parathyroid hormone (PTH) peptides have limited efficacy due to rapid clearance and short receptor binding. Here, the authors show that lipidation strategies can extend circulation time and receptor engagement, enhancing PTH peptide efficacy in vitro and in vivo

    • Jakob Höppner
    • Hiroshi Noda
    • Thomas J. Gardella
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

    • Federico Abascal
    • Reyes Acosta
    • Zhiping Weng
    ResearchOpen Access
    Nature
    Volume: 583, P: 699-710

  • G proteins are the key mediators of G protein-coupled receptor signalling, facilitating a number of important physiological processes. Now, the total synthesis and structure–activity relationship studies have been reported for the only known selective Gq protein inhibitors, the natural cyclic depsipeptides YM-254890 and FR900359.

    • Xiao-Feng Xiong
    • Hang Zhang
    • Kristian Strømgaard
    Research
    Nature Chemistry
    Volume: 8, P: 1035-1041

  • The authors summarize the history of the ENCODE Project, the achievements of ENCODE 1 and ENCODE 2, and how the new data generated and analysed in ENCODE 3 complement the previous phases.

    • Federico Abascal
    • Reyes Acosta
    • Richard M. Myers
    Reviews
    Nature
    Volume: 583, P: 693-698

  • This Review focuses on physiological and pathological aspects of the hormonal regulation of biomineralization, which is crucial for skeletal health during adulthood, fetal and neonatal development and pregnancy. The role of mineral intake, serum concentrations of mineral and hormonal regulators of biomineralization are highlighted.

    • Andrew Arnold
    • Elaine Dennison
    • Rajesh V. Thakker
    Reviews
    Nature Reviews Endocrinology
    Volume: 17, P: 261-275