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Showing 1–5 of 5 results
Advanced filters: Author: Michael R. Lazear Clear advanced filters

  • A deep chemical proteomic investigation of diverse aminophilic electrophiles has identified ligandable lysines across a wide range of human proteins. The proteins cover different functional and structural classes, and the aminophilic electrophiles include compounds that disrupt protein–protein and protein–RNA interactions. This dataset provides a proteome-wide atlas of lysine-reactive chemistry.

    • Mikail E. Abbasov
    • Madeline E. Kavanagh
    • Benjamin F. Cravatt
    Research
    Nature Chemistry
    Volume: 13, P: 1081-1092

  • A chemical proteomic strategy has now been reported for the global profiling of lysine reactivity and ligandability. Using this approach, >9000 lysines in the human proteome were evaluated, leading to the discovery of hyper-reactive lysines, and lysines that can be targeted by electrophilic small molecules to perturb enzyme function and protein–protein interactions.

    • Stephan M. Hacker
    • Keriann M. Backus
    • Benjamin F. Cravatt
    Research
    Nature Chemistry
    Volume: 9, P: 1181-1190