Nature Search

Two distinct mechanisms of immune suppression by antibody

MICHAEL K. HOFFMANN
JOHN W. KAPPLER
Research02 Mar 1978
Nature

Volume: 272, P: 64-65
Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

William S. Chen
Cheri S. Lazar
Michael G. Rosenfeld
Research27 Aug 1987
Nature

Volume: 328, P: 820-823
Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues

Light-sheet microscopes are increasingly used for imaging cleared tissues, but have imposed constraints on sample geometries and protocols. Here the authors present a multi-immersion open-top light-sheet microscope to overcome these limitations and enable high-throughput imaging of samples processed with various clearing protocols.

Adam K. Glaser
Nicholas P. Reder
Jonathan T. C. Liu
ResearchOpen Access04 Jul 2019
Nature Communications

Volume: 10, P: 1-8
Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut

Zinc is an essential cofactor for bacterial metabolism. Here, the authors show that the probiotic bacterium Escherichia coli Nissle 1917 utilizes the siderophore yersiniabactin as a zincophore, allowing the microbe to grow in zinc-limited media and to thrive in the inflamed gut.

Judith Behnsen
Hui Zhi
Manuela Raffatellu
ResearchOpen Access01 Dec 2021
Nature Communications

Volume: 12, P: 1-15
A hybrid open-top light-sheet microscope for versatile multi-scale imaging of cleared tissues

A ‘hybrid’ open-top light-sheet microscope is described, which can be used for broad multi-scale volumetric imaging of one or more large tissues, cleared with diverse protocols, and conveniently mounted on an array of sample holders.

Adam K. Glaser
Kevin W. Bishop
Jonathan T. C. Liu
Research11 May 2022
Nature Methods

Volume: 19, P: 613-619
Immune homeostasis enforced by co-localized effector and regulatory T cells

Autoantigen-presenting dendritic cells are shown to interact with both effector and regulatory T cells, and effector-produced IL-2 activates the transcription factor STAT5 in regulatory T cells, which in turn upregulates suppressive molecules and prevents autoimmunity.

Zhiduo Liu
Michael Y. Gerner
Ronald N. Germain
Research25 Nov 2015
Nature

Volume: 528, P: 225-230
Lymphoid stromal cells proGrem dendritic cell homeostasis

Single-cell technologies reveal the building blocks of secondary lymphoid organs, identifying Grem1⁺ fibroblastic reticular cells (FRCs) as critical niche cells that contribute to resident dendritic cell homeostasis and T cell immunity.

Antonio P. Baptista
Michael Y. Gerner
News & Views26 Apr 2021
Nature Immunology

Volume: 22, P: 541-543
High-dimensional cell-level analysis of tissues with Ce3D multiplex volume imaging

Li et al. detail a protocol for clearing-enhanced 3D (Ce3D), a method for tissue clearing, multiplexed immunofluorescence, RNA FISH microscopy of whole-mount tissues/thick tissue slices, and quantitative image analysis with volumetric histocytometry.

Weizhe Li
Ronald N. Germain
Michael Y. Gerner
Protocols26 Apr 2019
Nature Protocols

Volume: 14, P: 1708-1733
In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity

Vaccine efficacy is enhanced by optimizing the design of polymeric particles for adjuvant and antigen delivery.

Geoffrey M Lynn
Richard Laga
Robert A Seder
Research26 Oct 2015
Nature Biotechnology

Volume: 33, P: 1201-1210
Defining CD8⁺ T cells that provide the proliferative burst after PD-1 therapy

Chronic infection with lymphocytic choriomeningitis virus promotes the establishment of a population of stem-like PD-1⁺ CD8⁺ T cells that reside in lymphoid tissues and preferentially expand when the PD-1 inhibitory pathway is blocked.

Se Jin Im
Masao Hashimoto
Rafi Ahmed
Research02 Aug 2016
Nature

Volume: 537, P: 417-421
Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism

Distinct populations of lymphocytes act sequentially during development to direct maturation of the mammalian gut microbiota.

Kairui Mao
Antonio P. Baptista
Ronald N. Germain
Research22 Jan 2018
Nature

Volume: 554, P: 255-259
Dichotic Listening before and after Fluoxetine Treatment for Major Depression: Relations of Laterality to Therapeutic Response

Gerard E Bruder
Michael W Otto
Frederic M Quitkin
Research01 Aug 1996
Neuropsychopharmacology

Volume: 15, P: 171-179
Octenidine-based hydrogel shows anti-inflammatory and protease-inhibitory capacities in wounded human skin

Saskia Seiser
Lukas Janker
Adelheid Elbe-Bürger
ResearchOpen Access08 Jan 2021
Scientific Reports

Volume: 11, P: 1-13
Morpho‐metabotyping the oxidative stress response

Mate Rusz
Giorgia Del Favero
Gunda Koellensperger
ResearchOpen Access29 Jul 2021
Scientific Reports

Volume: 11, P: 1-12
Multidimensional differences of right- and left-sided colorectal cancer and their impact on targeted therapies

Marwa Abdel Hamid
Lorenz M. Pammer
Andreas Seeber
ReviewsOpen Access22 Apr 2025
npj Precision Oncology

Volume: 9, P: 1-13
Invasive Escherichia coli are a feature of Crohn's disease

Maiko Sasaki
Shanti V Sitaraman
Jan-Michael A Klapproth
Research30 Jul 2007
Laboratory Investigation

Volume: 87, P: 1042-1054

Search

Two distinct mechanisms of immune suppression by antibody

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues

Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut

A hybrid open-top light-sheet microscope for versatile multi-scale imaging of cleared tissues

Immune homeostasis enforced by co-localized effector and regulatory T cells

Lymphoid stromal cells proGrem dendritic cell homeostasis

High-dimensional cell-level analysis of tissues with Ce3D multiplex volume imaging

In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity

Defining CD8⁺ T cells that provide the proliferative burst after PD-1 therapy

Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism

Dichotic Listening before and after Fluoxetine Treatment for Major Depression: Relations of Laterality to Therapeutic Response

Octenidine-based hydrogel shows anti-inflammatory and protease-inhibitory capacities in wounded human skin

Morpho‐metabotyping the oxidative stress response

Multidimensional differences of right- and left-sided colorectal cancer and their impact on targeted therapies

Invasive Escherichia coli are a feature of Crohn's disease

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