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Showing 1–11 of 11 results

Advanced filters: Author: Michel J. Grothe Clear advanced filters

Four distinct trajectories of tau deposition identified in Alzheimer’s disease

Systematic characterization of longitudinal tau variability in human Alzheimer’s disease using an unbiased subtyping algorithm reveals four trajectories of tau deposition with distinct clinical features.

Jacob W. Vogel
Alexandra L. Young
Oskar Hansson
Research29 Apr 2021
Nature Medicine

Volume: 27, P: 871-881
Neurogenetic contributions to amyloid beta and tau spreading in the human cortex

Cross-sectional and longitudinal PET imaging of amyloid beta and tau in the human brain is combined with gene expression profiles to define the interactions between Alzheimer’s disease-related pathology propagation and brain-region-specific vulnerability.

Jorge Sepulcre
Michel J. Grothe
Keith A. Johnson
Research29 Oct 2018
Nature Medicine

Volume: 24, P: 1910-1918
The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment

Jessica Peter
Isabella Mayer
Michael Orth
ResearchOpen Access09 Aug 2021
Scientific Reports

Volume: 11, P: 1-7
A molecular gradient along the longitudinal axis of the human hippocampus informs large-scale behavioral systems

The human hippocampus plays a role in many different cognitive systems. Here the authors find that a single pattern of brain gene expression can predict how different parts of the hippocampus interact with the rest of the brain.

Jacob W. Vogel
Renaud La Joie
Alan C. Evans
ResearchOpen Access19 Feb 2020
Nature Communications

Volume: 11, P: 1-17
Data-driven characterization of distinct cognitive subtypes in Parkinson’s disease dementia

Miguel A. Labrador-Espinosa
Jesús Silva-Rodríguez
Michel J. Grothe
ResearchOpen Access09 May 2025
npj Parkinson's Disease

Volume: 11, P: 1-10
Cortical hypometabolism in Parkinson’s disease is linked to cholinergic basal forebrain atrophy

Miguel A. Labrador-Espinosa
Jesús Silva-Rodriguez
Michel J. Grothe
Research05 Dec 2024
Molecular Psychiatry

Volume: 30, P: 2372-2380
Reduced basal forebrain atrophy progression in a randomized Donepezil trial in prodromal Alzheimer’s disease

Enrica Cavedo
Michel J. Grothe
Marie Sarazin
ResearchOpen Access15 Sept 2017
Scientific Reports

Volume: 7, P: 1-10
Basal forebrain volume and metabolism in carriers of the Colombian mutation for autosomal dominant Alzheimer’s disease

Stefan Teipel
Alice Grazia
Nunzio Pomara
ResearchOpen Access17 May 2024
Scientific Reports

Volume: 14, P: 1-11
The BDNF_Val66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease

Nicolai Franzmeier
Jinyi Ren
Michael Ewers
Research21 Mar 2019
Molecular Psychiatry

Volume: 26, P: 614-628
Lower cholinergic basal forebrain volumes link with cognitive difficulties in schizophrenia

Mihai Avram
Michel J. Grothe
Christian Sorg
ResearchOpen Access29 Jun 2021
Neuropsychopharmacology

Volume: 46, P: 2320-2329
Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen

Martin Michaelis
Bishr Agha
Jindrich Cinatl jr.
ResearchOpen Access03 Feb 2015
Scientific Reports

Volume: 5, P: 1-9