The universal control of cell functions at single-cell level through artificial modulation of extracellular microenvironments by mimicking the natural extracellular matrices (ECMs) would be a key technique for biomedical fields. In the present review, fabrication of nanometer-sized artificial ECM films using various polymers and proteins on single-cell surfaces to control cell functions is described. The simple coating techniques reported here have opened a new window as a key technique for control of the extracellular microenvironments in tissue engineering, pharmaceutical and pathophysiological fields.
- Michiya Matsusaki
- Mitsuru Akashi
