Nature Search

Heart failure-specific cardiac fibroblasts contribute to cardiac dysfunction via the MYC–CXCL1–CXCR2 axis

Komuro et al. identify a heart failure-specific subpopulation of cardiac fibroblasts that promotes cardiac dysfunction via the MYC–CXCL1–CXCR2 axis, highlighting a potential therapeutic target beyond cardiomyocytes.

Jin Komuro
Hisayuki Hashimoto
Masaki Ieda
ResearchOpen Access10 Sept 2025
Nature Cardiovascular Research

Volume: 4, P: 1135-1151
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1

The plant AUG-stop element in the 5′ UTR acts as a boron concentration sensor, regulating downstream ORF translation. Here, structural and biochemical analyses show that a high concentration of borate fixes eRF1 on 80S ribosomes, preventing sliding through downstream of AUG-stop elements.

Mayuki Tanaka
Takeshi Yokoyama
Toru Fujiwara
Research24 Jan 2024
Nature Chemical Biology

Volume: 20, P: 605-614
Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A

SV2A is a receptor for botulinum neurotoxin (BoNT) and new generation antiepileptic drugs (AEDs). Here the authors report cryo-EM structures of SV2A in complex with BoNT receptor binding domain and AEDs highlighting the difference in the binding affinity between AEDs.

Atsushi Yamagata
Kaori Ito
Mikako Shirouzu
ResearchOpen Access18 Apr 2024
Nature Communications

Volume: 15, P: 1-13
Extremely low-frequency electromagnetic field (ELF-EMF) enhances mitochondrial energy production in NARP cybrids

Mikako Ito
Zhizhou Huang
Kinji Ohno
ResearchOpen Access08 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis

Cardiac fibrosis is a hallmark of heart failure. Here the authors use single-cell RNA-sequencing, spatial transcriptomics, and genetic manipulations, to show that Htra3 regulates cardiac fibrosis by keeping fibroblasts quiescent and by degrading TGF-beta.

Toshiyuki Ko
Seitaro Nomura
Issei Komuro
ResearchOpen Access07 Jun 2022
Nature Communications

Volume: 13, P: 1-17
Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction

Komuro et al. performed an integrative analysis of single-nucleus RNA sequencing and spatial transcriptome analysis of the injured heart to map cellular and molecular changes across topographical domains relative to the site of injury, and they identify that mechano-sensing genes at the border zone act as adaptive regulators of left ventricular remodeling.

Shintaro Yamada
Toshiyuki Ko
Issei Komuro
ResearchOpen Access17 Nov 2022
Nature Cardiovascular Research

Volume: 1, P: 1072-1083
Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling

Perivascular adipose tissue (PVAT) has been reported to undergo inflammatory changes in response to vascular injury. Here, the authors show that vascular injury induces the beiging (brown adipose tissue-like phenotype change) of PVAT, which fine-tunes inflammatory response as a protective mechanism.

Yusuke Adachi
Kazutaka Ueda
Issei Komuro
ResearchOpen Access07 Sept 2022
Nature Communications

Volume: 13, P: 1-14
B cell-derived GABA elicits IL-10⁺ macrophages to limit anti-tumour immunity

A paper in Nature demonstrates that B cell-derived GABA promotes monocyte differentiation into anti-inflammatory macrophages able to limit anti-tumour T cell cytotoxicity.

Baihao Zhang
Alexis Vogelzang
Sidonia Fagarasan
ResearchOpen Access03 Nov 2021
Nature

Volume: 599, P: 471-476
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression

This study describes RK-701, an inhibitor of histone methyltransferases G9a/GLP, as a promising therapeutic candidate for sickle cell disease and a universal role of BGLT3 lncRNA in fetal hemoglobin reactivation by chemical inducers including RK-701.

Shohei Takase
Takashi Hiroyama
Akihiro Ito
ResearchOpen Access12 Jan 2023
Nature Communications

Volume: 14, P: 1-18
Multicenter study on caries risk assessment in adults using survival Classification and Regression Trees

Masumi Arino
Ataru Ito
Mikako Hayashi
ResearchOpen Access06 Jul 2016
Scientific Reports

Volume: 6, P: 1-7
Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin

Takehiro Shinoda
Naoko Shinya
Mikako Shirouzu
ResearchOpen Access20 Sept 2016
Scientific Reports

Volume: 6, P: 1-10
Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22

LGI1 is an epilepsy-related gene that encodes a secreted neuronal protein. Here the authors present the crystal structure of LGI1 bound to its receptor ADAM22, which provides structural insights into epilepsy-causing LGI1 mutations and might facilitate the development of novel anti-epilepsy drugs.

Atsushi Yamagata
Yuri Miyazaki
Shuya Fukai
ResearchOpen Access18 Apr 2018
Nature Communications

Volume: 9, P: 1-13
Isoprenoid-chained lipid EROCOC₁₇₊₄: a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography

Kentaro Ihara
Masakatsu Hato
Mikako Shirouzu
ResearchOpen Access09 Nov 2020
Scientific Reports

Volume: 10, P: 1-12
Epigenetic mechanisms to propagate histone acetylation by p300/CBP

Histone acetylation activates gene transcription but its direct read/write mechanism is unknown. Here the authors show by cryo-electron microscopy that p300/CBP reads acetylation at histone H4 and writes it to other histones in the nucleosome.

Masaki Kikuchi
Satoshi Morita
Takashi Umehara
ResearchOpen Access17 Jul 2023
Nature Communications

Volume: 14, P: 1-16
Structural genomics projects in Japan

Shigeyuki Yokoyama
Hiroshi Hirota
Seiki Kuramitsu
Reviews01 Nov 2000
Nature Structural Biology

Volume: 7, P: 943-945
Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis

A number of testes-specific lncRNAs have been annotated but their roles remain largely unexplored. Here the authors identify two small peptides encoded by the lncRNA Gm9999, Kastor and Polluks, both of which are required for male fertility in mice.

Shintaro Mise
Akinobu Matsumoto
Keiichi I. Nakayama
ResearchOpen Access28 Feb 2022
Nature Communications

Volume: 13, P: 1-17
IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Kofuji et al. demonstrate that upregulation of IMPDH2 promotes nucleostemin stabilization and nucleoli malformation, and its inactivation induces growth arrest in glioblastoma.

Satoshi Kofuji
Akiyoshi Hirayama
Atsuo T. Sasaki
Research01 Aug 2019
Nature Cell Biology

Volume: 21, P: 1003-1014
RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing

Alternative pre-mRNA splicing is often jointly controlled by multiple splicing factors. Here Muto and colleagues elucidate the structural basis for cooperative RNA recognition by two splicing regulators required for tissue-specific expression of C. elegans FGFR.

Kanako Kuwasako
Mari Takahashi
Yutaka Muto
Research17 Aug 2014
Nature Structural & Molecular Biology

Volume: 21, P: 778-786
Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior

Fagarasan and colleagues show that excessive activation of T cells in mice deficient in the inhibitory receptor PD-1 causes a systemic decrease in tryptophan and tyrosine, which leads to deficiency in serotonin and dopamine in the brain and behavioral changes.

Michio Miyajima
Baihao Zhang
Sidonia Fagarasan
Research23 Oct 2017
Nature Immunology

Volume: 18, P: 1342-1352
The Wnt/β-catenin signaling pathway has a healing ability for periapical periodontitis

Haruna Naruse
Shousaku Itoh
Mikako Hayashi
ResearchOpen Access04 Oct 2021
Scientific Reports

Volume: 11, P: 1-9
Raf/MAPK and rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells

Taisei Kinoshita
Mikako Shirouzu
Atsushi Miyajima
Research07 Aug 1997
Oncogene

Volume: 15, P: 619-627
Inhibition of protein SUMOylation by natural quinones

Isao Fukuda
Mikako Hirohama
Minoru Yoshida
Research09 Mar 2016
The Journal of Antibiotics

Volume: 69, P: 776-779
Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region

Hideo Nakamura
Mitsuhiro Yoshida
Hideyuki Saya
Research05 Mar 1998
Oncogene

Volume: 16, P: 1009-1019
Biallelic TEDC1 variants cause a new syndrome with severe growth impairment and endocrine complications

Noriko Miyake
Kentaro Shiga
Naomichi Matsumoto
Research20 Feb 2025
European Journal of Human Genetics

Volume: 33, P: 738-746
Cell-free methods to produce structurally intact mammalian membrane proteins

Takehiro Shinoda
Naoko Shinya
Shigeyuki Yokoyama
ResearchOpen Access28 Jul 2016
Scientific Reports

Volume: 6, P: 1-15
Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata

Misao Takemoto
Yumi Kawamura
Minoru Yoshida
Research15 Jan 2014
The Journal of Antibiotics

Volume: 67, P: 335-338
R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5

Hiroaki Nakashima
Bisei Ohkawara
Kinji Ohno
ResearchOpen Access22 Jun 2016
Scientific Reports

Volume: 6, P: 1-14
Erratum: Four parameters increase the sensitivity and specificity of the exon array analysis and disclose 25 novel aberrantly spliced exons in myotonic dystrophy

Yoshihiro Yamashita
Tohru Matsuura
Kinji Ohno
Amendments and Corrections25 Jun 2012
Journal of Human Genetics

Volume: 57, P: 401
Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease

Hiroshi Nishiwaki
Jun Ueyama
Kinji Ohno
ResearchOpen Access21 May 2024
npj Parkinson's Disease

Volume: 10, P: 1-11
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study

Ryohei Yamamoto
Enyu Imai
Hiroyuki Komatsu
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
Gut microbiota in dementia with Lewy bodies

Hiroshi Nishiwaki
Jun Ueyama
Kinji Ohno
ResearchOpen Access09 Dec 2022
npj Parkinson's Disease

Volume: 8, P: 1-10
Extremely low-frequency pulses of faint magnetic field induce mitophagy to rejuvenate mitochondria

The effect of extremely low-frequency pulses of faint magnetic field on mitochondria is investigated, where it led to reduced mitochondrial mass, membrane potential and electron transport chain activity, and induced mitophagy.

Takuro Toda
Mikako Ito
Kinji Ohno
ResearchOpen Access12 May 2022
Communications Biology

Volume: 5, P: 1-11
Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson’s disease

Hiroshi Nishiwaki
Mikako Ito
Kinji Ohno
ResearchOpen Access01 Jun 2022
npj Parkinson's Disease

Volume: 8, P: 1-12
Zonisamide ameliorates progression of cervical spondylotic myelopathy in a rat model

Shunsuke Kanbara
Bisei Ohkawara
Kinji Ohno
ResearchOpen Access04 Aug 2020
Scientific Reports

Volume: 10, P: 1-13
Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis

Toshiaki Okura
Bisei Ohkawara
Kinji Ohno
ResearchOpen Access26 Feb 2019
Scientific Reports

Volume: 9, P: 1-10
Differential effects of spinal motor neuron-derived and skeletal muscle-derived Rspo2 on acetylcholine receptor clustering at the neuromuscular junction

Jin Li
Mikako Ito
Kinji Ohno
ResearchOpen Access11 Sept 2018
Scientific Reports

Volume: 8, P: 1-14
Inhibition of cyclooxygenase-1 by nonsteroidal anti-inflammatory drugs demethylates MeR2 enhancer and promotes Mbnl1 transcription in myogenic cells

Kun Huang
Akio Masuda
Kinji Ohno
ResearchOpen Access13 Feb 2020
Scientific Reports

Volume: 10, P: 1-14
Collagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling

Kenji Otsuka
Mikako Ito
Kinji Ohno
ResearchOpen Access10 Sept 2015
Scientific Reports

Volume: 5, P: 1-14
Molecular hydrogen suppresses activated Wnt/β-catenin signaling

Yingni Lin
Bisei Ohkawara
Kinji Ohno
ResearchOpen Access25 Aug 2016
Scientific Reports

Volume: 6, P: 1-14
SRSF1 suppresses selection of intron-distal 5′ splice site of DOK7 intron 4 to generate functional full-length Dok-7 protein

Khalid Bin Ahsan
Akio Masuda
Kinji Ohno
ResearchOpen Access05 Sept 2017
Scientific Reports

Volume: 7, P: 1-12
HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA

Mohammad Alinoor Rahman
Akio Masuda
Kinji Ohno
ResearchOpen Access14 Oct 2013
Scientific Reports

Volume: 3, P: 1-11
CUGBP1 and MBNL1 preferentially bind to 3′ UTRs and facilitate mRNA decay

Akio Masuda
Henriette Skovgaard Andersen
Kinji Ohno
ResearchOpen Access04 Jan 2012
Scientific Reports

Volume: 2, P: 1-10
Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy

Guiying Chen
Akio Masuda
Kinji Ohno
ResearchOpen Access29 Apr 2016
Scientific Reports

Volume: 6, P: 1-11
Necessity of salt intake reduction education beginning in youth: a cross-sectional survey of sodium-to-potassium ratios in mothers and their preschool children

Kenichiro Yasutake
Mikako Nagafuchi
Munechika Enjoji
Research20 Jul 2021
Hypertension Research

Volume: 44, P: 1307-1315
Review of 40 genes causing congenital myasthenic syndromes

Kinji Ohno
Mikako Ito
Bisei Ohkawara
ReviewsOpen Access18 Jun 2025
Journal of Human Genetics

P: 1-10
Author Correction: Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis

Toshiaki Okura
Bisei Ohkawara
Kinji Ohno
Amendments and CorrectionsOpen Access14 Feb 2020
Scientific Reports

Volume: 10, P: 1-2
Four parameters increase the sensitivity and specificity of the exon array analysis and disclose 25 novel aberrantly spliced exons in myotonic dystrophy

Yoshihiro Yamashita
Tohru Matsuura
Kinji Ohno
Research19 Apr 2012
Journal of Human Genetics

Volume: 57, P: 368-374

Search

Filter By:

Search

Quick links