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Showing 1–4 of 4 results
Advanced filters: Author: Mikel Garcia-Marcos Clear advanced filters

  • Broadly applicable genetically encoded probes and peptide-based compounds specifically inhibit Gαs, the prototypical signal transducer of G-protein-coupled receptors, providing new mechanistic insights into signaling at the subcellular scale.

    • Jingyi Zhao
    • Alex Luebbers
    • Mikel Garcia-Marcos
    Research
    Nature Chemical Biology
    P: 1-14

  • GPCRs are selective for specific G-protein subtypes, thereby ensuring signaling fidelity. A new report finds that that empty-like G-protein mutants are promiscuously recognized by GPCRs, suggesting that receptors select cognate over non-cognate G proteins at steps preceding nucleotide release.

    • Mikel Garcia-Marcos
    News & Views
    Nature Chemical Biology
    Volume: 19, P: 665-666

  • Nonreceptor guanine-nucleotide exchange factors (GEFs) are emerging as important regulators of heterotrimeric G proteins. Here, the authors present structural and mechanistic insights into how a class of nonreceptor GEFs containing the Ga-Binding and Activating motif interact and modulate G proteins.

    • Alain Ibáñez de Opakua
    • Kshitij Parag-Sharma
    • Mikel Garcia-Marcos
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16