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Showing 1–20 of 20 results
Advanced filters: Author: Mikiko C. Siomi Clear advanced filters

  • In S. pombe, small non-coding RNA mediates heterochromatin formation by recruiting the nucleosome remodeling and histone deacetylase complex. Here, the authors show that fly nucleosome remodeler Mi-2 and histone deacetylase Rpd3 are involved in piRNA-dependent transcriptional silencing of transposable elements.

    • Bruno Mugat
    • Simon Nicot
    • Séverine Chambeyron
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • PIWI-interacting RNAs (piRNAs) are a class of small RNAs that are known to associate with the PIWI proteins Argonaute 3, Aubergine and Piwi to silence retrotransposons in Drosophila germ lines. However, the primary processing pathway, one of two systems to produce piRNAs in Drosophila, remains incompletely characterized. Primary piRNA processing in a Drosophila ovarian somatic cell line is now analysed to reveal the large Maf gene traffic jam as a new piRNA cluster.

    • Kuniaki Saito
    • Sachi Inagaki
    • Mikiko C. Siomi
    Research
    Nature
    Volume: 461, P: 1296-1299

  • Zucchini has been identified as an endoribonuclease responsible for the maturation of small RNA molecules that protect the genome from the damaging effects of unrestrained expression of mobile elements.

    • Hiroshi Nishimasu
    • Hirotsugu Ishizu
    • Osamu Nureki
    Research
    Nature
    Volume: 491, P: 284-287

  • The identification of esiRNAs, a class of small RNAs, many of which are expressed from (and repress) retrotransposons, but in somatic cells. esiRNAs and piRNAs interact with different subfamilies of Argonaute proteins involved in RNAi.

    • Yoshinori Kawamura
    • Kuniaki Saito
    • Haruhiko Siomi
    Research
    Nature
    Volume: 453, P: 793-797

  • Previously, the molecular chaperone Hsp90 has been shown to copurify with RISC (RNA-induced silencing complex), involved in small RNA-mediated silencing. It is now shown that Hsp90 is needed for AGO2 to be loaded with a siRNA duplex by the RISC-loading complex suggesting a model where it is involved in modifying AGO2 conformation.

    • Tomohiro Miyoshi
    • Akiko Takeuchi
    • Mikiko C Siomi
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 1024-1026

  • The RNA-induced silencing complex (RISC) downregulates expression of the genes targeted by RNA-silencing pathways. But formation and turnover of the RISC complex itself is tightly regulated and requires endosomal membranes.

    • Haruhiko Siomi
    • Mikiko C Siomi
    News & Views
    Nature Cell Biology
    Volume: 11, P: 1049-1051

  • Siwi-piRISC protects the germline genome from DNA damage caused by selfish movement of transposons by suppressing their expression. Here, the authors show how molecularly Papi, which plays an important role in the production of Siwi-piRISC, cooperates with Par-1 kinase to ensure the accumulation of Siwi-piRISC in germ cells.

    • Hiromi Yamada
    • Kazumichi M. Nishida
    • Mikiko C. Siomi
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • PIWI-clade Argonautes bind PIWI-interacting RNAs (piRNAs) to silence transposons and maintain genome integrity in animal gonads. Here the authors present the crystal structure of a Drosophila Piwi–piRNA complex isolated from cultured fly ovarian somatic cells and find that it contains a non-canonical DVDK tetrad, and lacks slicer activity in vitro.

    • Sonomi Yamaguchi
    • Akira Oe
    • Osamu Nureki
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • The genome encodes thousands of small RNAs that interact with PIWI proteins; these PIWI-interacting RNAs (piRNAs) mediate silencing of transposable elements and thereby protect the genome. New insights are being gained into the formation and functions of piRNAs, and where they exert their action in the cell.

    • Mikiko C. Siomi
    • Kaoru Sato
    • Alexei A. Aravin
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 246-258

    • Mikiko C. Siomi
    Research Highlights
    Nature
    Volume: 461, P: 451

  • Recent progress in high-throughput sequencing has uncovered an astounding landscape of small RNAs in eukaryotic cells. Various small RNAs can be classified into three classes based on their biogenesis mechanism and the type of Argonaute protein that they are associated with.

    • V. Narry Kim
    • Jinju Han
    • Mikiko C. Siomi
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 10, P: 126-139

  • An endogenous small interfering RNA (endo-siRNA) pathway had only previously been characterized in worms. The recent discovery of diverse intramolecular and intermolecular substrates that generate endo-siRNAs in flies and mice raise many questions regarding the biogenesis and function of small regulatory RNAs in animals.

    • Katsutomo Okamura
    • Eric C. Lai
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 9, P: 673-678

  • Biomolecular liquid‒liquid phase separation (LLPS) is a critical process shaping cellular organization, particularly within the densely packed environment of the nucleus. Repetitive genomic elements, constituting nearly half of the human genome, play a pivotal role in regulating LLPS through interactions with associated proteins and RNAs. These sequences act as dynamic platforms for phase separation, influencing nuclear architecture and cellular phenotypes. This review highlights instances of LLPS formation within repetitive elements and explores their contributions to intermediate pathways and biomolecular complexes.

    • Sefan Asamitsu
    • Yuka W. Iwasaki
    Reviews
    Polymer Journal
    Volume: 57, P: 785-797