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Showing 1–3 of 3 results
Advanced filters: Author: Min-Chi Yeh Clear advanced filters

  • Homologous recombination is essential for DNA repair. Here, the authors present cryo-EM structures capturing five distinct intermediates of the RAD51 filament during strand exchange. These findings suggest a spatially coordinated, stepwise mechanism where the NTD guides DNA bending, while the L2 loop and S2 sites promote strand separation and product stabilization.

    • Shih-Chi Luo
    • Cheng-Han Yang
    • Meng-Chiao Ho
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-14

  • Vibrio α-hemolysins (αHLs) are toxins crucial for certain bacterial infections. Here the authors reveal that calcium ions boost the activity of a specific toxin, Vibrio campbellii αHL, and uncover its calcium-dependent activation mechanism.

    • Yu-Chuan Chiu
    • Min-Chi Yeh
    • Shih-Ming Lin
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • RAD51 filaments are essential for eukaryotic homologous recombination. This study shows the cryo-EM structure of an ADP-bound RAD51 double-filament that wraps around ssDNA revealing a stepwise collapsing mechanism for the transition between the ATP/ADP-bound filament intermediates.

    • Shih-Chi Luo
    • Min-Chi Yeh
    • Meng-Chiao Ho
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11