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Discovery of a peripheral 5HT_2A antagonist as a clinical candidate for metabolic dysfunction-associated steatohepatitis

Metabolic Dysfunction-Associated Steatohepatitis (MASH), an advanced form of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), can progress to liver fibrosis. Here, the authors develop a peripheral 5HT_2A antagonist for the treatment of MASLD and MASH.

Haushabhau S. Pagire
Suvarna H. Pagire
Jin Hee Ahn
ResearchOpen Access20 Jan 2024
Nature Communications

Volume: 15, P: 1-12
Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation

Osteoarthritis (OA) is associated with cartilage disruption, but the underlying mechanisms remain unclear. Here, the authors show that expression of osteoclast-associated receptor (OSCAR) is associated with OA, that its genetic ablation or targeting with OSCAR-Fc fusion protein ameliorates OA in mice by decreasing chondrocyte apoptosis.

Doo Ri Park
Jihee Kim
Soo Young Lee
ResearchOpen Access28 Aug 2020
Nature Communications

Volume: 11, P: 1-11
Directed evolution of CRISPR-Cas9 to increase its specificity

Undesired off-target effects can hamper the use of CRISPR-Cas9 in therapeutic applications. Here the authors use a directed evolution approach to develop Sniper-Cas9 which combines high specificity with no loss of on-target activity.

Jungjoon K. Lee
Euihwan Jeong
Jin-Soo Kim
ResearchOpen Access06 Aug 2018
Nature Communications

Volume: 9, P: 1-10
RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

Minhee Kim
Jin Hee Park
Soo Young Lee
ResearchOpen Access15 May 2024
Bone Research

Volume: 12, P: 1-14
Pim1 promotes the maintenance of bone homeostasis by regulating osteoclast function

Jeongin Seo
Ryeojin Ko
Soo Young Lee
ResearchOpen Access01 Apr 2025
Experimental & Molecular Medicine

Volume: 57, P: 733-744
Microbial copper reduction method to scavenge anthropogenic radioiodine

Seung Yeop Lee
Ji Young Lee
Yongjae Lee
ResearchOpen Access17 Jun 2016
Scientific Reports

Volume: 6, P: 1-7
Ocean fronts as decadal thermostats modulating continental warming hiatus

This paper shows the inherent coupling of winter cold extremes over land and marine heatwaves in the past decade. These events are projected to recur with increased frequency, especially when ocean fronts undergo anomalous decadal warming.

Mi-Kyung Sung
Soon-Il An
Minhee Chang
ResearchOpen Access27 Nov 2023
Nature Communications

Volume: 14, P: 1-10
Transfer learning prediction of type 2 diabetes with unpaired clinical and genetic data

YounSung Jung
SeanKyo Han
TaeJin Ahn
ResearchOpen Access29 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes

Fat distribution is associated with cardiometabolic disease, although it has been less well studied than overall obesity. In a multiancestry exome-sequencing study, the authors identified predicted loss-of-function mutations in INHBE associated with favorable fat distribution and protection from type 2 diabetes.

Parsa Akbari
Olukayode A. Sosina
Luca A. Lotta
ResearchOpen Access23 Aug 2022
Nature Communications

Volume: 13, P: 1-17
Author Correction: Identification of novel 7-hydroxycoumarin derivatives as ELOC binders with potential to modulate CRL2 complex formation

Yonghyeok Kim
Seon Jeong Baek
Byung Il Lee
Amendments and CorrectionsOpen Access07 Mar 2025
Scientific Reports

Volume: 15, P: 1-4
Identification of novel 7-hydroxycoumarin derivatives as ELOC binders with potential to modulate CRL2 complex formation

Yonghyeok Kim
Seon Jeong Baek
Byung Il Lee
ResearchOpen Access29 Jan 2025
Scientific Reports

Volume: 15, P: 1-9
Optimization of extraction-free protocols for SARS-CoV-2 detection using a commercial rRT-PCR assay

Minhee Kang
Eunjung Jeong
Nam Yong Lee
ResearchOpen Access21 Nov 2023
Scientific Reports

Volume: 13, P: 1-9
Targeting iron regulatory protein 2 (IRP2) to disrupt iron metabolism enhances radiosensitivity through mitochondrial dysfunction in breast cancer cells

Ye Yeong Jeong
Jieon Hwang
Sang Joon Shin
ResearchOpen Access31 Jul 2025
Cell Death Discovery

Volume: 11, P: 1-13
Yin Yang 1 is required for PHD finger protein 20-mediated myogenic differentiation in vitro and in vivo

Hyunji Lee
Youngeun Hong
Jisoo Park
Research18 Jun 2020
Cell Death & Differentiation

Volume: 27, P: 3321-3336
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease

Genome-wide meta-analysis of SARS-CoV-2 susceptibility and severity phenotypes in up to 756,646 samples identifies a rare protective variant proximal to ACE2. A 6-SNP genetic risk score provides additional predictive power when added to known risk factors.

Julie E. Horowitz
Jack A. Kosmicki
Manuel A. R. Ferreira
ResearchOpen Access03 Mar 2022
Nature Genetics

Volume: 54, P: 382-392
β-catenin activation down-regulates cell-cell junction-related genes and induces epithelial-to-mesenchymal transition in colorectal cancers

Won Kyu Kim
Yujin Kwon
Hoguen Kim
ResearchOpen Access05 Dec 2019
Scientific Reports

Volume: 9, P: 1-15
Rapid species identification of pathogenic bacteria from a minute quantity exploiting three-dimensional quantitative phase imaging and artificial neural network

Label-free rapid deep-learning-based identification of bacterial species that classifies 3D refractive index tomograms into the species.

Geon Kim
Daewoong Ahn
YongKeun Park
ResearchOpen Access23 Jun 2022
Light: Science & Applications

Volume: 11, P: 1-12
Fibrillin-1 mutant mouse captures defining features of human primary open glaucoma including anomalous aqueous humor TGF beta-2

MinHee K. Ko
Jeong-Im Woo
James C. Tan
ResearchOpen Access23 Jun 2022
Scientific Reports

Volume: 12, P: 1-16
The long-lasting post-stimulation inhibitory effects of bladder activity induced by posterior tibial nerve stimulation in unanesthetized rats

Eunkyoung Park
Jae-Woong Lee
Kyu-Sung Lee
ResearchOpen Access16 Nov 2020
Scientific Reports

Volume: 10, P: 1-10
Dose- and time-dependent effects of actomyosin inhibition on live mouse outflow resistance and aqueous drainage tissues

MinHee K. Ko
Eun Kyoung Kim
James C. Tan
ResearchOpen Access17 Feb 2016
Scientific Reports

Volume: 6, P: 1-12
Characterization of gene expression and activated signaling pathways in solid-pseudopapillary neoplasm of pancreas

Minhee Park
Minhyung Kim
Hoguen Kim
Research27 Sept 2013
Modern Pathology

Volume: 27, P: 580-593
Population-based study for the comorbidities and associated factors in Ménière’s disease

Min Hee Kim
ResearchOpen Access18 May 2022
Scientific Reports

Volume: 12, P: 1-8

Search

Discovery of a peripheral 5HT_2A antagonist as a clinical candidate for metabolic dysfunction-associated steatohepatitis

Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation

Directed evolution of CRISPR-Cas9 to increase its specificity

RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

Pim1 promotes the maintenance of bone homeostasis by regulating osteoclast function

Microbial copper reduction method to scavenge anthropogenic radioiodine

Ocean fronts as decadal thermostats modulating continental warming hiatus

Transfer learning prediction of type 2 diabetes with unpaired clinical and genetic data

Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes

Author Correction: Identification of novel 7-hydroxycoumarin derivatives as ELOC binders with potential to modulate CRL2 complex formation

Identification of novel 7-hydroxycoumarin derivatives as ELOC binders with potential to modulate CRL2 complex formation

Optimization of extraction-free protocols for SARS-CoV-2 detection using a commercial rRT-PCR assay

Targeting iron regulatory protein 2 (IRP2) to disrupt iron metabolism enhances radiosensitivity through mitochondrial dysfunction in breast cancer cells

Yin Yang 1 is required for PHD finger protein 20-mediated myogenic differentiation in vitro and in vivo

Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease

β-catenin activation down-regulates cell-cell junction-related genes and induces epithelial-to-mesenchymal transition in colorectal cancers

Rapid species identification of pathogenic bacteria from a minute quantity exploiting three-dimensional quantitative phase imaging and artificial neural network

Fibrillin-1 mutant mouse captures defining features of human primary open glaucoma including anomalous aqueous humor TGF beta-2

The long-lasting post-stimulation inhibitory effects of bladder activity induced by posterior tibial nerve stimulation in unanesthetized rats

Dose- and time-dependent effects of actomyosin inhibition on live mouse outflow resistance and aqueous drainage tissues

Characterization of gene expression and activated signaling pathways in solid-pseudopapillary neoplasm of pancreas

Population-based study for the comorbidities and associated factors in Ménière’s disease

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