Here, we introduce a candidate material, water-soluble guanidinylated chitosan (WGCS), for a protein delivery system. WGCS composed of 48.2% guanidinylated chitosan, 20.6% chitosan, and 31.2% chitin units was prepared from low-molecular-weight chitosan (CS). WGCS showed ca. 2.5-fold higher internalization into HeLa cells than CS does. Moreover, we found that WGCS significantly enhanced the internalization of bovine serum albumin in transport medium at pH 7.4.
- Hironori Izawa
- Ayaka Yagi
- Shinsuke Ifuku
