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Acta Pharmacologica Sinica (18)
Nature Communications (11)
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Showing 1–50 of 55 results

Advanced filters: Author: Ming-Ming Ma Clear advanced filters

Structural basis for IL-4 receptor phosphopeptide recognition by thelRS-1 PTB domain

Ming-Ming Zhou
Baohua Huang
Stephen W. Fesik
Research01 Apr 1996
Nature Structural Biology

Volume: 3, P: 388-393
Ketone α-alkylation at the more-hindered site

Ketone α-alkylation at the more hindered site is challenging. Here, the authors report a highly regioselective nickel-catalysed allylic alkylation of unsymmetrical ketones at the more-hindered α-site with allylic alcohols.

Ming-Ming Li
Tianze Zhang
Qi-Lin Zhou
ResearchOpen Access07 Jun 2023
Nature Communications

Volume: 14, P: 1-8
Structure and ligand recognition of the phosphotyrosine binding domain of Shc

Ming-Ming Zhou
Kodimangalam S. Ravichandran
Stephen W. Fesik
Research07 Dec 1995
Nature

Volume: 378, P: 584-592
Unique plastisphere viromes with habitat-dependent potential for modulating global methane cycle

Chen et al. reveal that plastisphere viral communities possess habitat-dependent potential for modulating global methane cycling. In aquatic environments, these viruses significantly promote methane emissions, emphasizing the significance of viruses in plastic pollution risk assessments.

Xue-Peng Chen
Dong Zhu
Yong-Guan Zhu
ResearchOpen Access29 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Structural mechanism of BRD4-NUT and p300 bipartite interaction in propagating aberrant gene transcription in chromatin in NUT carcinoma

BRD4-NUT’s bipartite binding and activation of p300 in NUT carcinoma nucleates a feed-forward spread of histone hyperacetylation and chromatin condensation that sustains aberrant pro-proliferation gene transcription and perpetual tumor cell growth.

Di Yu
Yingying Liang
Lei Zeng
ResearchOpen Access24 Jan 2023
Nature Communications

Volume: 14, P: 1-16
Deformation analysis of large-section quasi-rectangular shield construction on existing underground pipelines and power tunnel

Shi-ju Ma
Kai-rong Hong
Hai-quan Zhang
ResearchOpen Access26 Aug 2025
Scientific Reports

Volume: 15, P: 1-11
Measurement analysis of strata deformation caused by construction of quasi-rectangular shield

Shi-ju Ma
Kai-rong Hong
Xin-zhuang Lou
ResearchOpen Access06 Aug 2025
Scientific Reports

Volume: 15, P: 1-11
Machine learning-based extrachromosomal DNA identification in large-scale cohorts reveals its clinical implications in cancer

‘Extrachromosomal DNA has been previously linked to tumour progression and heterogeneity, but its potential as a cancer biomarker has not been fully explored. Here, the authors develop a computational framework to refine genomic subtypes and predict response to immunotherapy in gastrointestinal cancer.

Shixiang Wang
Chen-Yi Wu
Qi Zhao
ResearchOpen Access19 Feb 2024
Nature Communications

Volume: 15, P: 1-17
Genome-wide analysis of Cushion willow provides insights into alpine plant divergence in a biodiversity hotspot

Exceptional alpine plant diversity exists in the Hengduan Mountains. Here, through genome assembly and population genomics studies, the authors find notable intraspecific divergence among Cushion willow populations isolated by the sky island-like habitats and consider it contributes to speciation and biodiversity.

Jia-hui Chen
Yuan Huang
Hang Sun
ResearchOpen Access19 Nov 2019
Nature Communications

Volume: 10, P: 1-12
Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer

The molecular mechanism underlying the resistance of AKT inhibitors in breast cancer is still elusive. Here, the authors demonstrate that BRD4/FOXO3a axis upregulates CDK6 promoter activity to promote resistance to AKT inhibition in breast cancer cells and that blocking the action of CDK6 re-sensitizes resistant cancer cells to growth inhibition.

Jingyi Liu
Zhibing Duan
Jian Shi
ResearchOpen Access05 Dec 2018
Nature Communications

Volume: 9, P: 1-17
Phosphoribosylpyrophosphate synthetase as a metabolic valve advances Methylobacterium/Methylorubrum phyllosphere colonization and plant growth

A point mutation in the phosphoribosylpyrophosphate synthetase gene is found to rewire C1 metabolism and thereby enhance colonization capabilities and growth-promoting effects in plants. The effect of this mutation is prevalent across Methylobacterium strains.

Cong Zhang
Di-Fei Zhou
Song Yang
ResearchOpen Access16 Jul 2024
Nature Communications

Volume: 15, P: 1-16
Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy

Autonomic dysfunction is a feature of some α-synucleinopathies, but there are no models of pure autonomic dysfunction associated with α-synuclein. Here the authors describe a mouse model of pure autonomic dysfunction without motor dysfunciton by injection of pre-formed fibrils of α-synuclein to the stellate and celiac ganglia.

Xue-Jing Wang
Ming-Ming Ma
Xue-Bing Ding
ResearchOpen Access18 Feb 2020
Nature Communications

Volume: 11, P: 1-13
Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming

PFKFB3 enhances glycolysis to promote cancer cell proliferation. Here, the authors identify a long noncoding RNA in esophageal squamous cell carcinoma, AGPG, which interacts with PFKFB3 and promotes its stability, leading to increased glycolysis and proliferation.

Jia Liu
Ze-Xian Liu
Huai-Qiang Ju
ResearchOpen Access20 Mar 2020
Nature Communications

Volume: 11, P: 1-16
Neutralizing antibody durability and SARS-CoV-2 infection in older adults six months after XBB-containing vaccine booster

Rui-Rui Chen
Guo-Ping Cao
Mai-Juan Ma
ResearchOpen Access09 Oct 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-13
Comprehensive profiling of 1015 patients’ exomes reveals genomic-clinical associations in colorectal cancer

The ChangKang (Heathy Bowel) project was established to collect molecular and clinical information of a thousand Chinese colorectal cancer patients. Here, the authors present the genomic landscape of the ChangKang cohort and find a subgroup of patients defined by abnormal mitochondrial copy numbers.

Qi Zhao
Feng Wang
Rui-Hua Xu
ResearchOpen Access29 Apr 2022
Nature Communications

Volume: 13, P: 1-17
Proteomic analysis of HuH-7 cells harboring in vitro-transcribed full-length hepatitis C virus 1b RNA

Meng Xun
Si-hai Zhao
Yong-lie Chu
Research01 Jun 2008
Acta Pharmacologica Sinica

Volume: 29, P: 720-727
Epigenetic transcriptional repression of cellular genes by a viral SET protein

Viruses use various mechanisms to hijack cellular processes. Zhou and colleagues now describe a viral histone H3K27 methylase that modifies host histones and represses host target genes.

Shiraz Mujtaba
Karishma L. Manzur
Ming-Ming Zhou
Research17 Aug 2008
Nature Cell Biology

Volume: 10, P: 1114-1122
ZDHHC11 modulates innate immune response to DNA virus by mediating MITA–IRF3 association

Ying Liu
Qian Zhou
Shu Li
Research12 Feb 2018
Cellular & Molecular Immunology

Volume: 15, P: 907-916
Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated TMEM16A degradation

Can-zhao Liu
Fei-ya Li
Yong-yuan Guan
Research04 Sept 2019
Acta Pharmacologica Sinica

Volume: 41, P: 208-217
USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy

The regulatory mechanisms of PD-L1 posttranslational modifications are not completely understood. Here the authors show that USP8 negatively regulates PD-L1 protein abundance by removing the K63-linked ubiquitination of PD-L1; while USP8 inhibition increases MHC-I expression and triggers anti-tumour immune responses through activating NF-κB signalling.

Wenjun Xiong
Xueliang Gao
Jinfang Zhang
ResearchOpen Access31 Mar 2022
Nature Communications

Volume: 13, P: 1-17
Restoration of E-cadherin by PPBICA protects against cisplatin-induced acute kidney injury by attenuating inflammation and programmed cell death

Li Gao
Ming-Ming Liu
Xiao-Ming Meng
Research26 Mar 2018
Laboratory Investigation

Volume: 98, P: 911-923
Discovery of novel dual-target inhibitors of LSD1/EGFR for non-small cell lung cancer therapy

Yu Wei
Ming-ming Sun
Jian-ping Lin
ResearchOpen Access03 Jan 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1030-1044
A Multi-year Beneficial Effect of Seed Priming with Gibberellic Acid-3 (GA₃) on Plant Growth and Production in a Perennial Grass, Leymus chinensis

Hong-Yuan Ma
Dan-Dan Zhao
Zheng-Wei Liang
ResearchOpen Access04 Sept 2018
Scientific Reports

Volume: 8, P: 1-9
Dual antiplatelet therapy reduced stroke risk in transient ischemic attack with positive diffusion weighted imaging

Lu-lu Pei
Pei Chen
Bo Song
ResearchOpen Access05 Nov 2020
Scientific Reports

Volume: 10, P: 1-7
FBXW7 is a multifaceted regulator of the innate immune response to DNA viruses

Xue-Dan Sun
Jia-Li Wang
Ming-Ming Hu
Research08 Sept 2025
Cellular & Molecular Immunology

Volume: 22, P: 1427-1443
miR-511 promotes the proliferation of human hepatoma cells by targeting the 3′UTR of B cell translocation gene 1 (BTG1) mRNA

Shu-qin Zhang
Zhe Yang
Xiao-dong Zhang
Research12 Jun 2017
Acta Pharmacologica Sinica

Volume: 38, P: 1161-1170
Ivacaftor, a CFTR potentiator, synergizes with osimertinib against acquired resistance to osimertinib in NSCLC by regulating CFTR-PTEN-AKT axis

Yue-kang Li
Fu-jing Ge
Hong Zhu
Research03 Dec 2024
Acta Pharmacologica Sinica

Volume: 46, P: 1045-1057
Pretreatment with a combination of ligustrazine and berberine improves cardiac function in rats with coronary microembolization

Ying Zhang
Xiao-juan Ma
Da-zhuo Shi
Research29 Feb 2016
Acta Pharmacologica Sinica

Volume: 37, P: 463-472
WNK1 is required for proliferation induced by hypotonic challenge in rat vascular smooth muscle cells

Ya-juan Zhang
Hua-qing Zheng
Yong-yuan Guan
Research03 Aug 2017
Acta Pharmacologica Sinica

Volume: 39, P: 35-47
Targeting lysine acetylation readers and writers

Lysine acetylation is a post-translational modification on histones and other proteins that is catalysed by acetyltransferases (‘writers’) and mediates interactions with bromodomains and other ‘reader’ domains. This Review summarizes the properties and functions of these writers and readers and discusses efforts to identify small-molecule therapeutics that target them, some of which are being evaluated in clinical trials.

Ming-Ming Zhou
Philip A. Cole
Reviews21 Nov 2024
Nature Reviews Drug Discovery

Volume: 24, P: 112-133
LncRNA TMPO-AS1 promotes esophageal squamous cell carcinoma progression by forming biomolecular condensates with FUS and p300 to regulate TMPO transcription

Xiao-Jing Luo
Ming-Ming He
Hui-Yan Luo
ResearchOpen Access27 Jun 2022
Experimental & Molecular Medicine

Volume: 54, P: 834-847
Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson’s disease

Reduced meningeal lymphatic flow detected in patients with idiopathic Parkinson’s disease compared to patients with atypical Parkinsonian disorders and cognitively normal controls.

Xue-Bing Ding
Xin-Xin Wang
Xue-Jing Wang
Research18 Jan 2021
Nature Medicine

Volume: 27, P: 411-418
Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism

Ying Tan
Hong-hong Wan
Hu Peng
Research21 Apr 2020
Acta Pharmacologica Sinica

Volume: 42, P: 404-413
Identification and expression of DoCCaMK during Sebacina sp. symbiosis of Dendrobium officinale

Yong-Mei Xing
Ming-Ming Zhao
Shun-Xing Guo
ResearchOpen Access16 Jun 2020
Scientific Reports

Volume: 10, P: 1-10
In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-disc-associated mitigator of isoproterenol-induced cardiac injury

Cong-ting Guo
Blake D. Jardin
Yu-xuan Guo
Research23 Jul 2024
Acta Pharmacologica Sinica

Volume: 45, P: 2540-2552
Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta

Osteogenesis imperfecta (OI) is a debilitating illness marked by brittle bones and fractures, as well as extraskeletal abnormalities. Now, Ingo Grafe and colleagues show that both the dominant and recessive forms of this disease are caused by excessive TGF-β signaling and that targeting this pathway improves bone health in mouse models of OI.

Ingo Grafe
Tao Yang
Brendan Lee
Research04 May 2014
Nature Medicine

Volume: 20, P: 670-675
Preclinical pharmacokinetics of TPN729MA, a novel PDE5 inhibitor, and prediction of its human pharmacokinetics using a PBPK model

Zhi-wei Gao
Yun-ting Zhu
Da-fang Zhong
Research23 Nov 2015
Acta Pharmacologica Sinica

Volume: 36, P: 1528-1536
Vascular smooth muscle-specific LRRC8A knockout ameliorates angiotensin II-induced cerebrovascular remodeling by inhibiting the WNK1/FOXO3a/MMP signaling pathway

Feng-ting Lu
Cheng-cui Huang
Ming-ming Ma
Research08 May 2024
Acta Pharmacologica Sinica

Volume: 45, P: 1848-1860
Preoperative Heart Rate Variability as Predictors of Vagus Nerve Stimulation Outcome in Patients with Drug-resistant Epilepsy

Hong-Yun Liu
Zhao Yang
Lu-Ming Li
ResearchOpen Access01 Mar 2018
Scientific Reports

Volume: 8, P: 1-11
IMPDH inhibitors upregulate PD-L1 in cancer cells without impairing immune checkpoint inhibitor efficacy

Ming-ming Zheng
Jia-yi Li
Bo Yang
Research26 Nov 2024
Acta Pharmacologica Sinica

Volume: 46, P: 1058-1067
Discovery of a nitroaromatic nannocystin with potent in vivo anticancer activity against colorectal cancer by targeting AKT1

Han Zhang
Fei Xie
Chang-liang Shan
Research07 Feb 2024
Acta Pharmacologica Sinica

Volume: 45, P: 1044-1059
Clcn3 deficiency ameliorates high-fat diet-induced obesity and adipose tissue macrophage inflammation in mice

Ming-ming Ma
Chen-chen Jin
Guan-lei Wang
Research05 Jun 2019
Acta Pharmacologica Sinica

Volume: 40, P: 1532-1543
SGK1 mediates the hypotonic protective effect against H₂O₂-induced apoptosis of rat basilar artery smooth muscle cells by inhibiting the FOXO3a/Bim signaling pathway

Bao-yi Chen
Cheng-cui Huang
Yong-yuan Guan
Research05 Mar 2020
Acta Pharmacologica Sinica

Volume: 41, P: 1073-1084
Death-associated protein kinase 1 is an IRF3/7-interacting protein that is involved in the cellular antiviral immune response

Jing Zhang
Ming-Ming Hu
Shu Li
Research17 Feb 2014
Cellular & Molecular Immunology

Volume: 11, P: 245-252
β-adrenoreceptor-triggered PKA activation negatively regulates the innate antiviral response

Yi Guo
Xia-Nan Zhang
Hong-Bing Shu
Research05 Jan 2023
Cellular & Molecular Immunology

Volume: 20, P: 175-188
Stratifin promotes renal dysfunction in ischemic and nephrotoxic AKI mouse models via enhancing RIPK3-mediated necroptosis

Fang Wang
Jia-nan Wang
Juan Jin
Research08 Apr 2021
Acta Pharmacologica Sinica

Volume: 43, P: 330-341
Simulated atmospheric nitrogen deposition inhibited the leaf litter decomposition of Cinnamomum migao H. W. Li in Southwest China

Xiao-Long Huang
Jing-Zhong Chen
Ji-Ming Liu
ResearchOpen Access18 Jan 2021
Scientific Reports

Volume: 11, P: 1-13
DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits

Hsiang-Cheng Chi
Chung-Ying Tsai
Kwang-Huei Lin
Research04 Aug 2020
Oncogene

Volume: 39, P: 5933-5949
TSPO ligands prevent the proliferation of vascular smooth muscle cells and attenuate neointima formation through AMPK activation

Lian-pan Wu
Zheng-fan Gong
Chun-yu Zeng
Research12 Sept 2019
Acta Pharmacologica Sinica

Volume: 41, P: 34-46
CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis

Ying-nan Wang
Zhao-lei Zeng
Rui-hua Xu
Research11 Jul 2018
Oncogene

Volume: 37, P: 6025-6040

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