The development of robust, practical, and chemoselective methods for introducing the difluoromethyl (CF₂H) group into organic molecules is highly sought after in the fields of pharmaceutical and agrochemical design. Herein, the authors report a Fe/Ni dual-transition-metal electrocatalytic strategy for difluoromethylation of (hetero)aryl halides, using difluoroacetate — the most abundant source of the CF₂H group — as an effective difluoromethylating reagent.
- Naifu Zhou
- Mingding Chai
- Niankai Fu
