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In situ-generated vaccine-like pyroptosome for personalized cancer immunotherapy

An injectable pH-sensitive nanoadjuvant is shown to induce effective pyroptosis of tumours, which, combined with the in situ photoactivable release of TLR agonists, generates a strong vaccine-like response to eradicate the tumour.

Binlong Chen
Fangjie Wan
Yiguang Wang
Research03 Mar 2026
Nature Materials

P: 1-12
Solar hydrogen production through ambient-pressure seawater splitting

A donor–π–acceptor carbon nitride photocatalyst with enhanced charge separation enables efficient hydrogen production from natural seawater under ambient pressure and sunlight, advancing scalable green hydrogen generation.

Kui Li
Taizhong Xiao
Mingmei Wu
ResearchOpen Access16 Feb 2026
Nature Communications

Volume: 17, P: 1-16
Dynamic multicolor emissions of multimodal phosphors by Mn²⁺ trace doping in self-activated CaGa₄O₇

Achieving dynamic multimodal luminescence in a single material is promising but challenging. Here, the authors engineer a phosphor with dynamic multicolor luminescence and photo-thermomechanically responsive emissions by adding Mn²⁺ to a self-activated CaGa₄O₇ host.

Yiqian Tang
Yiyu Cai
Jun-Cheng Zhang
ResearchOpen Access13 Apr 2024
Nature Communications

Volume: 15, P: 1-15
Tuning nanoparticle core composition drives orthogonal fluorescence amplification for enhanced tumour imaging

Optical nanoprobes with preferential tumour accumulation is often limited by inefficient amplification of biological signals. Here, the authors report a hydrophobic core-tunable nanoprobe orthogonally amplifying tumour microenvironmental signals and demonstrating clear delineation between malignant lesions and normal tissues on multiple tumour models.

Meijie Pan
Ruiyang Zhao
Yiguang Wang
ResearchOpen Access07 Sept 2024
Nature Communications

Volume: 15, P: 1-16
pH-gated nanoparticles selectively regulate lysosomal function of tumour-associated macrophages for cancer immunotherapy

A high abundance of tumour associated macrophages with immunosuppressive properties is associated with inefficient anti-tumour immune responses. Here the authors report the design and characterization of pH-gated nanoparticles selectively targeting and reprogramming M2-like macrophages in the tumour microenvironment, re-sensitizing tumours to immune checkpoint blockade.

Mingmei Tang
Binlong Chen
Yiguang Wang
ResearchOpen Access21 Sept 2023
Nature Communications

Volume: 14, P: 1-16
Dissecting extracellular and intracellular distribution of nanoparticles and their contribution to therapeutic response by monochromatic ratiometric imaging

Detailed quantification of nanoparticle distribution in tumor tissues can provide the prediction of drug delivery efficacy and therapeutic outcome. Here the authors develop a pH/light dual responsive monochromatic ratiometric-imaging nanoparticle which can quantify extracellular and intracellular nanoparticle distribution in several tumor models.

Yue Yan
Binlong Chen
Yiguang Wang
ResearchOpen Access14 Apr 2022
Nature Communications

Volume: 13, P: 1-14
Quantitative imaging of intracellular nanoparticle exposure enables prediction of nanotherapeutic efficacy

Quantification of intratumoral nanoparticles internalisation in vivo is crucial but challenging. Here, the authors develop a binary ratiometric nanoreporter that can quantify internalisation and predict nanotherapeutic responses based on intracellular nanoparticle exposure.

Qingqing Yin
Anni Pan
Yiguang Wang
ResearchOpen Access22 Apr 2021
Nature Communications

Volume: 12, P: 1-13

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In situ-generated vaccine-like pyroptosome for personalized cancer immunotherapy

Solar hydrogen production through ambient-pressure seawater splitting

Dynamic multicolor emissions of multimodal phosphors by Mn2+ trace doping in self-activated CaGa4O7

Tuning nanoparticle core composition drives orthogonal fluorescence amplification for enhanced tumour imaging

pH-gated nanoparticles selectively regulate lysosomal function of tumour-associated macrophages for cancer immunotherapy

Dissecting extracellular and intracellular distribution of nanoparticles and their contribution to therapeutic response by monochromatic ratiometric imaging

Quantitative imaging of intracellular nanoparticle exposure enables prediction of nanotherapeutic efficacy

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Dynamic multicolor emissions of multimodal phosphors by Mn²⁺ trace doping in self-activated CaGa₄O₇