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C-type natriuretic peptide attenuates enhanced glycolysis and de novo pyrimidine synthesis in pericytes of patients with pulmonary arterial hypertension

CNP/cGMP signaling counteracts metabolic reprogramming in pulmonary arterial hypertension pericytes by reducing HIF1α, GLUT-1, and CAD activity, thereby normalizing glycolysis and pyrimidine synthesis and limiting hyperproliferation, highlighting its therapeutic potential.

Minhee Noh
Ankita Mitra
Swati Dabral
ResearchOpen Access12 Aug 2025
Communications Biology

Volume: 8, P: 1-16
Transfer learning prediction of type 2 diabetes with unpaired clinical and genetic data

YounSung Jung
SeanKyo Han
TaeJin Ahn
ResearchOpen Access29 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Targeting iron regulatory protein 2 (IRP2) to disrupt iron metabolism enhances radiosensitivity through mitochondrial dysfunction in breast cancer cells

Ye Yeong Jeong
Jieon Hwang
Sang Joon Shin
ResearchOpen Access31 Jul 2025
Cell Death Discovery

Volume: 11, P: 1-13
Implantable Photothermal Agents based on Gold Nanorods-Encapsulated Microcube

Hyun June Moon
Minhee Ku
Ki Wan Bong
ResearchOpen Access12 Sept 2018
Scientific Reports

Volume: 8, P: 1-12
C-type natriuretic peptide/cGMP/FoxO3 signaling attenuates hyperproliferation of pericytes from patients with pulmonary arterial hypertension

This study reveals that exogenous CNP counteracts growth factor-induced pericyte alterations by preserving FoxO3 activity. Thus, impaired signaling of endogenous, paracrine-acting CNP might contribute to vascular remodeling in patients with PAH.

Swati Dabral
Minhee Noh
Michaela Kuhn
ResearchOpen Access06 Jun 2024
Communications Biology

Volume: 7, P: 1-13
Beyond EGFR inhibition: multilateral combat strategies to stop the progression of head and neck cancer

Hyung Kwon Byeon
Minhee Ku
Jaemoon Yang
ReviewsOpen Access16 Jan 2019
Experimental & Molecular Medicine

Volume: 51, P: 1-14

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C-type natriuretic peptide attenuates enhanced glycolysis and de novo pyrimidine synthesis in pericytes of patients with pulmonary arterial hypertension

Transfer learning prediction of type 2 diabetes with unpaired clinical and genetic data

Targeting iron regulatory protein 2 (IRP2) to disrupt iron metabolism enhances radiosensitivity through mitochondrial dysfunction in breast cancer cells

Implantable Photothermal Agents based on Gold Nanorods-Encapsulated Microcube

C-type natriuretic peptide/cGMP/FoxO3 signaling attenuates hyperproliferation of pericytes from patients with pulmonary arterial hypertension

Beyond EGFR inhibition: multilateral combat strategies to stop the progression of head and neck cancer

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