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Showing 1–8 of 8 results
Advanced filters: Author: Mirela Kuka Clear advanced filters

  • The division of the immune system into innate and adaptive arms has become blurred in recent years. Kuka et al.identify a novel population of αβ-T-cell receptor-expressing cells in mice and humans that both presents and responds to antigen and produces interleukin-12, thus exhibiting core properties of both dendritic cells and T cells.

    • Mirela Kuka
    • Ivana Munitic
    • Jonathan D. Ashwell
    Research
    Nature Communications
    Volume: 3, P: 1-11

  • The development of multiphoton intravital microscopy has enabled detailed studies of humoral responses within lymphoid tissues. Here, Kuka and Iannacone cover recent studies of the viral subversion of B cell responses and discuss how these findings relate to our understanding of B cell activation within secondary lymphoid organs.

    • Mirela Kuka
    • Matteo Iannacone
    Reviews
    Nature Reviews Immunology
    Volume: 18, P: 255-265

  • The lysine-specific histone demethylase 1 A (LSD1) can regulate cytotoxic CD8 T cell (CTL) responses and anti-tumor immunity. Here the authors show that ex vivo epigenetic reprogramming with a LSD1 inhibitor enhances cell persistence and anti-tumor activity of adoptively transferred CD8 T cells in preclinical tumor models.

    • Isabella Pallavicini
    • Teresa Maria Frasconi
    • Teresa Manzo
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Here the authors use three different mouse models to show that prior infection or mRNA vaccination can protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) independently of antibodies, highlighting the importance of T cell-derived interferon-γ (IFN-γ) in host defense and the need to consider this measure of protection in vaccination.

    • Valeria Fumagalli
    • Micol Ravà
    • Matteo Iannacone
    ResearchOpen Access
    Nature Immunology
    Volume: 25, P: 633-643

  • Class switch recombination (CSR) is a process by which B cells switch their immunoglobulin isotype and develop pathogen-eliminating antibodies. Here, the authors show that a protein kinase DYRK1A is required for protection from viral infection through the regulation of CSR and effective clonal expansion.

    • Liat Stoler-Barak
    • Ethan Harris
    • Ziv Shulman
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15