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Showing 1–2 of 2 results
Advanced filters: Author: Miriam Doepner Clear advanced filters
  • Using two-photon intravital imaging, the authors show that mechanical stress in skin triggers fluid-filled “stress vesicles” in epidermal cells, altering Piezo1-dependent calcium signals to drive stem cell differentiation and protect tissue integrity.

    • Sixia Huang
    • Paola Kuri
    • Panteleimon Rompolas
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-18
  • Cutaneous hyperpigmented lesions, including nevi, are populated by senescent melanocytes. Here the authors provide evidence for a novel strategy based on combining inhibition of the BCL-2 and MCL1 anti-apoptotic pathways that selectively eliminates senescent melanocytes in culture and in vivo.

    • Jaskaren Kohli
    • Chen Ge
    • Marco Demaria
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12