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Showing 1–20 of 20 results
Advanced filters: Author: Miriam Regev Clear advanced filters

  • Nature Immunology’s 20th anniversary is a good opportunity to reminisce about the ImmGen collective endeavor — its goals, successes and horror stories — and the group’s exploration of various modes of scientific publishing.

    • Stephanie Vargas Aguilar
    • Oscar Aguilar
    • Caroline Ziemkiewicz
    Comments & Opinion
    Nature Immunology
    Volume: 21, P: 700-703

  • A new subset of disease-associated astrocytes (DAAs) is identified in a mouse model of Alzheimer’s disease by single-nucleus RNA sequencing. DAAs are also found in aged wild-type mice, suggesting a link to genetic and age-related factors.

    • Naomi Habib
    • Cristin McCabe
    • Michal Schwartz
    Research
    Nature Neuroscience
    Volume: 23, P: 701-706

  • The Human Cell Atlas (HCA) aims to characterize cells from diverse individuals across the globe to better understand human biology. Here, the authors lay out principles and action items that have been adopted to affirm HCA’s commitment to equity so that the atlas is beneficial to all of humanity.

    • Ido Amit
    • Kristin Ardlie
    • Xiaowei Zhuang
    ReviewsOpen Access
    Nature Communications
    Volume: 15, P: 1-7

  • Differentiating neutrophil functional states is difficult. Here the authors show, using single cell RNA-sequencing and trajectory analyses, that mouse neutrophils can be presented as a transcriptome continuum rather than discrete subsets, but are affected by inflammation to express distinct transcriptional states.

    • Ricardo Grieshaber-Bouyer
    • Felix A. Radtke
    • Hideyuki Yoshida
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-21

  • Helper T cell subsets are characterized functionally by the cytokines they produce. Benoist and colleagues demonstrate that in vivo helper T cells do not manifest as discrete helper subsets but rather form a continuum shaped by microbial exposure.

    • Evgeny Kiner
    • Elijah Willie
    • Hideyuki Yoshida
    Research
    Nature Immunology
    Volume: 22, P: 216-228

  • The transcriptional circuitry that controls the differentiation of hematopoietic stem cells into cells of the immune system is only partially understood. Koller and colleagues use a computational algorithm to identify previously unknown differentiation stage–specific regulators of mouse hematopoiesis.

    • Vladimir Jojic
    • Tal Shay
    • Shannon Turley
    Research
    Nature Immunology
    Volume: 14, P: 633-643

  • The transcriptional regulation of commitment to the dendritic cell (DC) lineage and functional specialization of DCs in vivo is poorly understood. In this Resource, Merad and colleagues identify the lineage relationships among various tissue DC subsets.

    • Jennifer C Miller
    • Brian D Brown
    • Christophe Benoist
    Research
    Nature Immunology
    Volume: 13, P: 888-899

  • Brown and colleagues generated an atlas of miRNA expression profiles from primary mouse immune cell populations and connected these signatures with ATAC–seq, ChIP–seq and nascent RNA profiles to establish a map of miRNA promoter and enhancer usage in immune cells.

    • Samuel A. Rose
    • Aleksandra Wroblewska
    • Aldrin Yim
    Research
    Nature Immunology
    Volume: 22, P: 914-927

  • What is the role and value of consortium biology in immunology? Here, the participants of the Immunological Genome Project share their thoughts on the benefits and shortcomings of 'big science' and discuss how the immunology community can profit from engaging in this type of discovery-led research.

    • Christophe Benoist
    • Lewis Lanier
    • Diane Mathis
    Comments & Opinion
    Nature Reviews Immunology
    Volume: 12, P: 734-740

  • Lanier and colleagues systematically define the transcriptome of mouse natural killer cells in several contexts, including activation states and relative to all other lymphocyte and myeloid populations profiled by the Immunological Genome Project consortium.

    • Natalie A Bezman
    • Charles C Kim
    • Christophe Benoist
    Research
    Nature Immunology
    Volume: 13, P: 1000-1009

  • As part of the Immunogical Genome project, Kang and colleagues compare the gene-expression profiles of emergent thymocytes from adult mice that express the γδ T cell antigen receptor, segregated on the basis of the use of the γ- or δ-chain variable region, and find that the main subsets are molecularly distinct.

    • Kavitha Narayan
    • Katelyn E Sylvia
    • Christophe Benoist
    Research
    Nature Immunology
    Volume: 13, P: 511-518

  • The differentiation of αβ T cells is a complex process. Using data sets from the Immunological Genome Project, Benoist and colleagues identify candidate mediators of key transitions during thymocyte selection and maturation.

    • Michael Mingueneau
    • Taras Kreslavsky
    • Shannon Turley
    Research
    Nature Immunology
    Volume: 14, P: 619-632