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Showing 1–6 of 6 results
Advanced filters: Author: Mithu Baidya Clear advanced filters

  • The targeting and modulation of G-protein-coupled receptors (GPCRs) has immense therapeutic potential. A study in Nature now reports on the successful targeting of intracellular allosteric sites that effectively bias GPCR signaling, which has opened new opportunities to develop safer therapeutic agents.

    • Neeraj Soni
    • Tarumoy Das
    • Mithu Baidya
    News & Views
    Nature Structural & Molecular Biology
    Volume: 30, P: 1612-1614

  • Interaction with heterotrimeric G proteins is a hallmark of G-protein-coupled receptor (GPCR) family members, and it is the key step for a diverse range of cell-signaling cascades. A recent cryo-EM structure of the human calcitonin receptor (CTR) in complex with a G-protein heterotrimer reveals novel insights into receptor–G-protein coupling.

    • Mithu Baidya
    • Hemlata Dwivedi
    • Arun K Shukla
    News & Views
    Nature Structural & Molecular Biology
    Volume: 24, P: 500-502

  • Analysis of 18 available structures and other data reveals a new, conserved structural motif in arrestins and suggests that different phosphorylation patterns of the GPCR C terminus can drive distinct arrestin conformations and functional outcomes.

    • Andrija Sente
    • Raphael Peer
    • Tilman Flock
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 538-545

  • This review summarizes how molecular chaperones enable structures of small inactive-state GPCRs by improving particle alignment and effective molecular weight, delivering high-resolution cryo-EM insights and guiding community decisions on stabilization strategies.

    • Swapnil Kumar Singh
    • Mahek Agrawal
    • Punita Kumari
    ReviewsOpen Access
    Communications Biology
    Volume: 9, P: 1-12