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Showing 1–3 of 3 results
Advanced filters: Author: Mitro Miihkinen Clear advanced filters

  • Treatment selection based on the presence of one or more specific biomarkers has the potential to optimize treatment outcomes; nonetheless, most patients lack a specific biomarker that is predictive of benefit from one or more targeted treatment approaches. In this Review, the authors describe the potential of computational analysis approaches to enable the discovery of more complex predictive biomarkers based on comprehensive analysis of large clinical and preclinical datasets and thus address this unmet need.

    • Xin Wang
    • Julia Nguyen
    • Benjamin Haibe-Kains
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 23, P: 180-200

  • Pluripotent stem cell colonies are encircled by large cornerstone focal adhesions (FAs). Here, using super-resolution imaging, the authors describe features in the nanoscale makeup of these stable FAs such as inverted vinculin, lateral talin segregation and distinct kank protein distributions.

    • Aki Stubb
    • Camilo Guzmán
    • Johanna Ivaska
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Hundreds of computational resources have been developed that can be applied to repurposing existing drugs for new indications, making it challenging to select the right resource for a specific project. To help address this challenge, this article provides an overview of computational approaches to drug repurposing based on a comprehensive survey of available resources classified into hierarchical categories for a web catalogue, and presents an expert evaluation of selected resources, as well as case studies to illustrate their application.

    • Ziaurrehman Tanoli
    • Adrià Fernández-Torras
    • Tero Aittokallio
    Reviews
    Nature Reviews Drug Discovery
    Volume: 24, P: 521-542