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Showing 1–9 of 9 results
Advanced filters: Author: Mizuki Wakabayashi Clear advanced filters

  • A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

    • Ryuya Edahiro
    • Go Sato
    • Yukinori Okada
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 1905-1921

  • Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

    • Qingbo S. Wang
    • Ryuya Edahiro
    • Yukinori Okada
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

    • Ho Namkoong
    • Ryuya Edahiro
    • Yukinori Okada
    ResearchOpen Access
    Nature
    Volume: 609, P: 754-760

  • Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

    • Noah Sasa
    • Shohei Kojima
    • Yukinori Okada
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 65-79

  • Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

    • Ryuya Edahiro
    • Yuya Shirai
    • Yukinori Okada
    ResearchOpen Access
    Nature Genetics
    Volume: 55, P: 753-767

  • A total of 1074 patients with a history of ischemic stroke enrolled in The Recurrent Stroke Prevention Clinical Outcome (RESPECT) Study were assigned to intensive blood pressure (BP) control group (blood pressure < 120/80 mmHg) or standard blood pressure control group (blood pressure < 140/90 mmHg) and were followed up for a mean of 3.9 years. Seventy-eight first recurrent strokes occurred, including 70 ischemic stroke and 8 intracerebral hemorrhage. Intensive treatment did not change annual risk of ischemic stroke (1.74% vs. 1.75%, P = 0.999), but markedly reduced risk of hemorrhagic stroke (0.00% vs. 0.39%, P = 0.005). Beneficial effect of intensive BP control were observed for risk of hemorrhagic stroke in the patients with a history of ischemic stroke.

    • Kazuo Kitagawa
    • Hisatomi Arima
    • Seigo Nakada
    Research
    Hypertension Research
    Volume: 45, P: 591-601

  • We visualized the spatial inhomogeneity of chain orientation on the submicron scale in high-density polyethylene associated with strain-induced density fluctuations using STXM and USAXS/SAXS/WAXD. Real-space images of the density fluctuations were obtained with STXM at the strain where a butterfly pattern was observed with USAXS. STXM observation also revealed that the chains in the low-density region were more often oriented parallel to the stretching direction than those in the high-density region.

    • Masato Arakawa
    • Mizuki Kishimoto
    • Mikihito Takenaka
    Research
    Polymer Journal
    Volume: 54, P: 243-248