Oxa-spirocyclic compounds are valuable in pharmaceuticals, yet their synthesis remains challenging. Here, the authors develop a cobalt(III)-catalyzed synthesis using phenoxy acetamide and alkynes via exclusive 1,2-carboamidation, achieving high yields and enabling complex molecular architectures.
- Bholanath Garai
- Molla Rahamat Ali
- Basker Sundararaju
