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Gene Therapy (1)
Nature Biomedical Engineering (1)

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Advanced filters: Author: Morten Seirup Clear advanced filters

Rational immunosilencing of a promiscuous T-cell epitope in the capsid of an adeno-associated virus

Replacing amino acid residues in an immunodominant and conserved T-cell epitope in the capsid of an adeno-associated virus widely used in gene therapies abrogates its immunogenicity while preserving its function and potency.

So Jin Bing
Morten Seirup
Ronit Mazor
Research23 Nov 2023
Nature Biomedical Engineering

Volume: 8, P: 193-200
Unveiling the sex bias: higher preexisting and neutralizing titers against AAV in females and implications for gene therapy

Stephanee Warrington
Trish T. Hoang
Ronit Mazor
Research05 May 2025
Gene Therapy

Volume: 32, P: 339-348

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Rational immunosilencing of a promiscuous T-cell epitope in the capsid of an adeno-associated virus

Unveiling the sex bias: higher preexisting and neutralizing titers against AAV in females and implications for gene therapy

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