Cleavage Under Targets & Tagmentation is a rapidly expanding technique, but thorough evaluation and benchmarking against established ChIP-seq datasets are required. This study shows that CUT&Tag recovers ~54% of ENCODE peaks for H3K27ac/H3K27me3 in K562 cells, with CUT&Tag peaks mapping to key cell type-specific regulatory regions.
- Leyla Abbasova
- Paulina Urbanaviciute
- Sarah J. Marzi
