Nature Search

Prospective evaluation of genomics-guided off-label treatment

Evaluation by the Drug Rediscovery Protocol of off-label use of 37 approved cancer drugs on 1,610 patients showed modest activities overall, although subgroups of responders suggest that off-label drug use could be beneficial in tandem with more stringent biomarker selection.

K. Verkerk
A. C. Spiekman
F. Jeurissen
ResearchOpen Access15 Apr 2026
Nature

P: 1-9
Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

Damaris Kinyoki
Aaron E. Osgood-Zimmerman
Simon I. Hay
ResearchOpen Access12 Oct 2021
Nature Medicine

Volume: 27, P: 1761-1782
Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

Roy Burstein
Nathaniel J. Henry
Simon I. Hay
ResearchOpen Access16 Oct 2019
Nature

Volume: 574, P: 353-358
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
ResearchOpen Access20 Apr 2020
Nature Medicine

Volume: 26, P: 750-759
Mapping routine measles vaccination in low- and middle-income countries

Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.

Alyssa N. Sbarra
Sam Rolfe
Jonathan F. Mosser
ResearchOpen Access16 Dec 2020
Nature

Volume: 589, P: 415-419
Using Satellite Images in Determination of Malaria Outbreaks Potential Region

Abolfazl Ahmadian Marj
Mohammad Reza Mobasheri
Mohammad Reza Abaie
ResearchOpen Access26 Sept 2008
Nature Precedings

P: 1
Mapping disparities in education across low- and middle-income countries

Analyses of the proportions of individuals who have completed key levels of schooling across all low- and middle-income countries from 2000 to 2017 reveal inequalities across countries as well as within populations.

Nicholas Graetz
Lauren Woyczynski
Simon I. Hay
ResearchOpen Access25 Dec 2019
Nature

Volume: 577, P: 235-238
Mapping child growth failure across low- and middle-income countries

High-resolution subnational mapping of child growth failure indicators for 105 low- and middle-income countries between 2000 and 2017 shows that, despite considerable progress, substantial geographical inequalities still exist in some countries.

Damaris K. Kinyoki
Aaron E. Osgood-Zimmerman
Simon I. Hay
ResearchOpen Access08 Jan 2020
Nature

Volume: 577, P: 231-234
Association between effectiveness of treatment with curative intent and outcomes of first-line systemic therapy in metachronous metastatic gastroesophageal adenocarcinoma

D. Kamp
A. M. May
N. Haj Mohammad
Research26 Mar 2026
British Journal of Cancer

P: 1-9
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
Amendments and CorrectionsOpen Access02 Jul 2020
Nature Medicine

Volume: 26, P: 1308
The climate benefit of seagrass blue carbon is reduced by methane fluxes and enhanced by nitrous oxide fluxes

Methane and nitrous oxide release from seagrass ecosystems offset around 7% to 33% of the global climate benefits of atmospheric carbon dioxide drawdown by seagrasses, suggest in situ measurements and a global synthesis of seagrass greenhouse gas fluxes and long-term organic carbon burial rates.

Bradley D. Eyre
Nicola Camillini
Judith A. Rosentreter
ResearchOpen Access13 Oct 2023
Communications Earth & Environment

Volume: 4, P: 1-9
Treatment for unresectable or metastatic oesophageal cancer: current evidence and trends

Approximately half of patients diagnosed with oesophageal cancer have metastatic or unresectable disease. Here, the authors discuss the multidisciplinary interventions available to manage dysphagia, improve quality of life and prolong survival in these individuals.

Peter S. N. van Rossum
Nadia Haj Mohammad
Richard van Hillegersberg
Reviews13 Dec 2017
Nature Reviews Gastroenterology & Hepatology

Volume: 15, P: 235-249

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