Nature Search

Alternating arginine-modulated substrate specificity in an engineered tyrosine aminotransferase

Vladimir N. Malashkevich
James J. Onuffer
Johan N. Jansonius
Research01 Jul 1995
Nature Structural Biology

Volume: 2, P: 548-553
Conformational biosensors delineate endosomal G protein regulation by GPCRs

Many GPCRs signal from endosomes, which requires active G proteins at this location. Here, the authors describe how active Gα_s accumulates on endosomes and reveal location-biased selectivity in GPCR-mediated G protein activation.

Brian Wysolmerski
Nicole M. Fisher
Mark von Zastrow
ResearchOpen Access18 Feb 2026
Nature Communications

Volume: 17, P: 1-15
γδ T cell-derived IL-4 initiates CD8⁺ T cell immunity

The authors show how Vγ1⁺ γδ T cells produce IL-4 to drive early CD8⁺ T cell and dendritic cell responses to malaria infection in mice.

Shirley Le
Nick Dooley
Lynette Beattie
ResearchOpen Access30 Jan 2026
Nature Immunology

Volume: 27, P: 295-307
Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor

Shigetada Nakanishi
Akira Inoue
Shosaku Numa
Research29 Mar 1979
Nature

Volume: 278, P: 423-427
Influence of Ribonucleic Acids from the Liver on Implantation and Growth of Transplantable Tumours

N. N. AKSENOVA
V. M. BRESLER
J. M. OLENOV
Research03 Nov 1962
Nature

Volume: 196, P: 443-444
Estimation of Mass-Scattering Coefficient of Biological Samples

N. H. SARKAR
P. SADHUKHAN
Research30 Mar 1963
Nature

Volume: 197, P: 1263-1264
A new symmetrical polarization structure near the galactic centre

J. H. Seiradakis
A. N. Lasenby
U. Klein
Research24 Oct 1985
Nature

Volume: 317, P: 697-699
Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus

N. Kitamura
A. Kitamura
M. Yoshida
Research20 May 1982
Nature

Volume: 297, P: 205-208
Dentatorubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p

S. Nagafuchi
H. Yanagisawa
M. Yamada
Research01 Jan 1994
Nature Genetics

Volume: 6, P: 14-18
Is CO₂ responsible for the outbursts of comet Halley?

P. D. Feldman
M. F. A'Hearn
T. N. Woods
Research04 Dec 1986
Nature

Volume: 324, P: 433-436
Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm–egg fusion in mice

Sperm-egg fusion is facilitated by the sperm-specific receptor IZUMO1 and the egg-specific counter-receptor JUNO. Here Inoue et al.show that JUNO first binds to monomeric IZUMO1; IZUMO1 then dimerizes and excludes JUNO from the sperm-egg interface, suggesting the existence of a IZUMO1 dimer receptor.

Naokazu Inoue
Yoshihisa Hagihara
Ikuo Wada
ResearchOpen Access16 Nov 2015
Nature Communications

Volume: 6, P: 1-12
The Possibility of distinguishing between Substances shown on Electron Micrographs

ROBIN C. VALENTINE
Research14 Mar 1959
Nature

Volume: 183, P: 761
A new mode of X-ray bursts from MXB1730–335

H. Inoue
K. Koyama
K. Yamashita
Research24 Jan 1980
Nature

Volume: 283, P: 358-360
Theoretical Limiting Thicknesses for Single Scattering in Electron Microscopy

N. R. SILVESTER
R. E. BURGE
Research19 Nov 1960
Nature

Volume: 188, P: 641-643
Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling

ADGRF1 is an adhesion GPCR that signals when a bound ligand induces liberation of an intramolecular tethered agonist. Here, the authors show that ADGRF1 can signal though all major G protein classes and identify a structural basis for Gq selectivity.

Daniel T. D. Jones
Andrew N. Dates
Stephen C. Blacklow
ResearchOpen Access29 Apr 2023
Nature Communications

Volume: 14, P: 1-13
Minimum Mass-Thickness and its Effect on the Measurement of Dimension of Carbonaceous Objects from their Negative Electron Micrographs

N. H. SARKAR
Research07 Mar 1964
Nature

Volume: 201, P: 983-985
Self-organizing glycolytic waves tune cellular metabolic states and fuel cancer progression

Glycolytic enzymes form self-organized traveling waves at the cell membrane/cortex, boosting local ATP production and cell movement. Cancer cells with intense waves rely more on glycolysis for energy, potentially explaining the Warburg effect.

Huiwang Zhan
Dhiman Sankar Pal
Peter N. Devreotes
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-19
Radio-interferometric imaging of the subsurface emissions from the planet Mercury

J. O. Burns
G. R. Gisler
M. Zeilik
Research17 Sept 1987
Nature

Volume: 329, P: 224-226
Experimental investigation of geologically produced antineutrinos with KamLAND

T. Araki
S. Enomoto
F. Piquemal
Research28 Jul 2005
Nature

Volume: 436, P: 499-503
Designing allosteric modulators to change GPCR G protein subtype selectivity

Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching receptor subtype preference.

Madelyn N. Moore
Kelsey L. Person
Lauren M. Slosky
ResearchOpen Access22 Oct 2025
Nature

Volume: 648, P: 229-238
Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging

Here, the authors identify the microbiota-derived corisin as a driver of diabetic kidney fibrosis via cellular aging and show that targeting corisin with a monoclonal antibody alleviates disease in mice, suggesting a potential therapeutic avenue.

Taro Yasuma
Hajime Fujimoto
Esteban C. Gabazza
ResearchOpen Access25 Aug 2025
Nature Communications

Volume: 16, P: 1-29
Intracellular calcium ions decrease the affinity of the GABA receptor

M. Inoue
Y. Oomura
N. Akaike
Research13 Nov 1986
Nature

Volume: 324, P: 156-158
The reeler gene encodes a protein with an EGF–like motif expressed by pioneer neurons

S. Hirotsune
T. Takahara
Y. Hayashizaki
Research01 May 1995
Nature Genetics

Volume: 10, P: 77-83
Lesions due to Complement in Lipid Membranes

T. R. HESKETH
R. R. DOURMASHKIN
P. J. LACHMANN
Research29 Oct 1971
Nature

Volume: 233, P: 620-623
Efficient cellular transformation via protein delivery through the protrusion-derived extracellular vesicles

The efficiency of protein transfer by extracellular vesicles (EVs) remains unclear. Here, authors show that EVs from cell protrusions deliver functional Rac1 and genome-editing enzymes more efficiently than well-studied endosome-derived EVs, highlighting their potential as delivery tools.

Toshifumi Fujioka
Tamako Nishimura
Shiro Suetsugu
ResearchOpen Access08 Dec 2025
Nature Communications

Volume: 16, P: 1-21
A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density

N. Ota
T. Nakajima
M. Emi
Research01 Apr 2001
Journal of Human Genetics

Volume: 46, P: 267-272
Observation of neutral modes in the fractional quantum Hall regime

The quantum Hall effect takes place in a two-dimensional electron gas under a strong magnetic field and involves current flow along the edges of the sample. In the fractional regime, counter-propagating modes that carry energy but not charge — the so-called neutral modes — have been predicted but never observed. These authors report the first direct observation of these elusive modes.

Aveek Bid
N. Ofek
D. Mahalu
Research29 Jul 2010
Nature

Volume: 466, P: 585-590
Noncanonical translation via deadenylated 3′ UTRs maintains primordial germ cells

Primordazine inhibits poly(A)-tail-independent noncanonical translation (PAINT) in early zebrafish embryos and in mammalian cells under select conditions, an effect mediated by deadenylated 3ʹ UTRs that results in ablation of primordial germ cells.

Youngnam N. Jin
Peter J. Schlueter
Randall T. Peterson
Research09 Jul 2018
Nature Chemical Biology

Volume: 14, P: 844-852
Spin-down episode of the X-ray pulsar Vela X-1

F. Nagase
S. Hayakawa
K. Yamashita
Research16 Apr 1981
Nature

Volume: 290, P: 572-573
Rate of Micelle Formation of Sodium Alkyl Sulphates in Water

P. F. MIJNLIEFF
R. DITMARSCH
Research27 Nov 1965
Nature

Volume: 208, P: 889-891
A class of benzofuranoindoline-bearing heptacyclic fungal RiPPs with anticancer activities

Here the authors report asperigimycins, fungal ribosomally synthesized and post-translationally modified peptides with a heptacyclic scaffold. After chemically modifying them for nanomolar anticancer activity, CRISPR screening identifies SLC46A3 as a key transporter for their uptake in cells.

Qiuyue Nie
Fanglong Zhao
Xue Gao
Research23 Jun 2025
Nature Chemical Biology

Volume: 21, P: 1938-1947
Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15

Here the authors show that the basal activation of the interferon/ISG15 pathway is required for the stability of nascent DNA during replication and its upregulation promotes viability, proliferation and acquisition of drug resistance in BRCA1/2 deficient cells.

Ramona N. Moro
Uddipta Biswas
Lorenza Penengo
ResearchOpen Access02 Oct 2023
Nature Communications

Volume: 14, P: 1-15
Deacetylation as a receptor-regulated direct activation switch for pannexin channels

Pannexin 1 (PANX1) is a membrane channel mediating release of signaling molecules to the extracellular space. PANX1 can be activated by GPCRs. Here, the authors elucidate a non-canonical channel activation pathway by α1-adrenergic receptor that involves HDAC6- mediated lysine deacetylation of PANX1.

Yu-Hsin Chiu
Christopher B. Medina
Douglas A. Bayliss
ResearchOpen Access23 Jul 2021
Nature Communications

Volume: 12, P: 1-14
Discovery of an unusual hard X-ray source in the region of supernova 1987A

T. Dotani
K. Hayashida
D. H. Reading
Research19 Nov 1987
Nature

Volume: 330, P: 230-231
Burdens of type 2 diabetes and cardiovascular disease attributable to sugar-sweetened beverages in 184 countries

Estimates from the Global Dietary Database indicated that 2.2 million new type 2 diabetes and 1.2 million new cardiovascular disease cases were attributable to sugar-sweetened beverages worldwide in 2020, with the highest burdens in sub-Saharan Africa, Latin America and the Caribbean.

Laura Lara-Castor
Meghan O’Hearn
Rubina Hakeem
ResearchOpen Access06 Jan 2025
Nature Medicine

Volume: 31, P: 552-564
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Thermospheric 63-µm, emission of atomic oxygen in local thermodynamic equilibrium

N. Iwagami
T. Ogawa
Research29 Jul 1982
Nature

Volume: 298, P: 454-455
A 300 kilobase interval genetic map of rice including 883 expressed sequences

N. Kurata
Y. Nagamura
Y. Minobe
Research01 Dec 1994
Nature Genetics

Volume: 8, P: 365-372
High-resolution imaging from Mauna Kea: the triple quasar in 0.3-arc s seeing

J. Patrick Henry
J. N. Heasley
Research08 May 1986
Nature

Volume: 321, P: 139-142
A modular tool to query and inducibly disrupt biomolecular condensates

Here, the authors present DisCo (Disassembly of Condensates), a method that allows the fast, inducible, and specific disruption of tagged condensates in mammalian cells. DisCo uses chemical dimerizers to induce the recruitment of a ligand into condensates leading to condensate disassembly.

Carmen N. Hernández-Candia
Sarah Pearce
Chandra L. Tucker
ResearchOpen Access22 Mar 2021
Nature Communications

Volume: 12, P: 1-13
Comparison of radiobiological effective depths in 65-MeV modulated proton beams

JT Tang
T Inoue
K Hatanaka
Research01 Jul 1997
British Journal of Cancer

Volume: 76, P: 220-225
VLBI imaging with an angular resolution of 100 microarcseconds

N. Bartel
V. Dhawan
A. C. S. Readhead
Research14 Jul 1988
Nature

Volume: 334, P: 131-135
Novel nickel-functionalized glycoboehmite materials for iodide and arsenate capture

Jessica N. Kruichak
Nelson S. Bell
Edward N. Matteo
ResearchOpen Access13 Nov 2025
Scientific Reports

Volume: 15, P: 1-12
Photochemical attachment of cyclic AMP binding protein(s) to the nuclear genome

John Kallos
Research24 Feb 1977
Nature

Volume: 265, P: 705-710
Extremely-high-velocity H₂0 maser emission in the galaxy NGC4258

N. Nakai
M. Inoue
M. Miyoshi
Research07 Jan 1993
Nature

Volume: 361, P: 45-47
Iron-sensing and redox properties of the hemerythrin-like domains of Arabidopsis BRUTUS and BRUTUS-LIKE2 proteins

BRUTUS proteins are thought to act as iron sensors in plants. In-vitro studies provide biochemical evidence for the sensor function, demonstrating dynamic, redox-dependent iron binding to the unusual triple hemerythrin-like domain.

Jacob Pullin
Jorge Rodríguez-Celma
Janneke Balk
ResearchOpen Access24 Apr 2025
Nature Communications

Volume: 16, P: 1-13
Why leaves are sometimes red

Kevin S. Gould
David N. Kuhn
Steven F. Oberbauer
Research16 Nov 1995
Nature

Volume: 378, P: 241-242
Infra-red Emission Spectra of Minerals

M. J. D. Low
Research11 Dec 1965
Nature

Volume: 208, P: 1089-1090
Nucleic Acid of Infectious Laryngotracheitis Virus

G. A. TANNOCK
Research13 Nov 1965
Nature

Volume: 208, P: 711-712
The shape, expansion rate and distance of supernova 1993J from VLBI measurements

N. Bartel
M. F. Bietenholz
R. J. Davis
Research14 Apr 1994
Nature

Volume: 368, P: 610-613

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