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Advanced filters: Author: Nader Morshed Clear advanced filters

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder

Here authors show loss of AKAP11, a strong genetic risk factor for bipolar disorder and schizophrenia, disrupts PKA proteostasis and signaling, leading to widespread transcriptomic alterations across the brain, particularly in striatal neurons, as well as altered behavior.

Bryan J. Song
Yang Ge
Morgan Sheng
ResearchOpen Access28 Nov 2025
Nature Communications

Volume: 16, P: 1-25
Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer’s disease

Morshed et al. analyzed the proteome and phosphoproteome of brain tissue from patients with Alzheimer’s disease. The analysis of patient heterogeneity links glia pathologies and signaling pathways to stages of disease progression.

Nader Morshed
Meelim J. Lee
Forest M. White
Research14 Jun 2021
Nature Aging

Volume: 1, P: 550-565
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease

The ratio between the levels of two synaptic proteins in cerebrospinal fluid predicts future cognitive resilience versus decline among presymptomatic individuals and individuals with early Alzheimer’s disease harboring amyloid and tau pathology.

Hamilton Se-Hwee Oh
Deniz Yagmur Urey
Tony Wyss-Coray
ResearchOpen Access31 Mar 2025
Nature Medicine

Volume: 31, P: 1592-1603

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