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Showing 1–2 of 2 results
Advanced filters: Author: Nadezhda Fefelova Clear advanced filters

  • Nakada, Titus et al. show that p22phox, a heterodimeric partner of NADPH oxidases, prevents sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a (SERCA2a) oxidation at Cys498 and its downregulation. This study suggests that therapeutic interventions to protect this residue may sustain SERCA2a expression in heart failure.

    • Yasuki Nakada
    • Allen Sam Titus
    • Junichi Sadoshima
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 4, P: 1187-1205

  • The anti-apoptotic function of Bcl-xL in the heart is diminished by Mst1-mediated phosphorylation of Serine14. Here, the authors show that the Bcl-xL phosphorylation is also promoted by hemodynamic stress, which plays an essential role in mediating compensatory cardiac hypertrophy and contractility.

    • Michinari Nakamura
    • Mariko Aoyagi Keller
    • Junichi Sadoshima
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15