Nature Search

Integrated multi-omic atlas reveals the hierarchy of spatiotemporal regulatory networks of mouse gastrulation

Spatiotemporal coordination of cellular and molecular events is crucial for cell fate commitment. Here, Yang et al. describe how transcription factors, signaling pathways, and epigenomic states regulate left-right patterning and axial mesendoderm lineage commitment during mouse gastrulation.

Xianfa Yang
Bingbing Xie
Naihe Jing
ResearchOpen Access12 Jan 2026
Nature Communications

P: 1-22
Id proteins sustain Hes1 expression to maintain neural stem cells

Ge Bai
Nengyin Sheng
Naihe Jing
Research04 Aug 2008
Cell Research

Volume: 18, P: S19
Author Correction: Molecular architecture of lineage allocation and tissue organization in early mouse embryo

Guangdun Peng
Shengbao Suo
Naihe Jing
Amendments and Corrections16 Sept 2020
Nature

Volume: 586, P: E7
Author Correction: Molecular architecture of lineage allocation and tissue organization in early mouse embryo

Guangdun Peng
Shengbao Suo
Naihe Jing
Amendments and Corrections03 Jan 2020
Nature

Volume: 577, P: E6
Transcription factor ZNF263 primes human embryonic stem cells for pluripotency dissolution and lineage commitment

Human embryonic stem cells are simultaneously capable of self-renewal and poised for differentiation. Here, the authors show a role for the ZNF263 transcription factor promotes primed pluripotency and facilitates differentiation into primary germ layer lineages.

Qianqian Yin
Jing Huang
Zhen Shao
ResearchOpen Access05 Nov 2025
Nature Communications

Volume: 16, P: 1-21
Author Correction: Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation

Neophytos Christodoulou
Christos Kyprianou
Magdalena Zernicka-Goetz
Amendments and Corrections19 Nov 2018
Nature Cell Biology

Volume: 20, P: 1434
Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation

Gastrulation entails a series of events that are highly coordinated in space and time. Here they construct a spatiotemporal molecular atlas of lineage trajectories in the gastrulating mouse embryo by mapping single cells to spatial coordinates in the germ layers with reference to positional data in the transcriptome.

Ran Wang
Xianfa Yang
Naihe Jing
ResearchOpen Access14 Sept 2023
Nature Communications

Volume: 14, P: 1-18
Publisher Correction: Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures

Berna Sozen
Gianluca Amadei
Magdalena Zernicka-Goetz
Amendments and Corrections08 Aug 2018
Nature Cell Biology

Volume: 20, P: 1229
Molecular architecture of lineage allocation and tissue organization in early mouse embryo

Spatially resolved transcriptomes of cell populations at defined positions in the early mouse embryo reveal molecular bases of lineage specification and tissue patterning.

Guangdun Peng
Shengbao Suo
Naihe Jing
Research07 Aug 2019
Nature

Volume: 572, P: 528-532
Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate

Differentiation of embryonic stem cells (ESCs) into neural lineages involves epigenetic changes. Here the authors show that transient histone deacetylation promotes the transition from epiblast stem cells to neural progenitors during mouse ESC differentiation and show that this effect is partly mediated by the restriction of Nodal signalling by histone deacetylase 1.

Pingyu Liu
Xiaoyang Dou
Naihe Jing
Research23 Apr 2015
Nature Communications

Volume: 6, P: 1-14
Transplantation of marrow stromal cells to rescue retinal cells in SI-induced retinal degeneration in rats

Yuan Guan
Lu Cui
Guo-Tong Xu
Research04 Aug 2008
Cell Research

Volume: 18, P: S152
Inference of differentiation time for single cell transcriptomes using cell population reference data

Single cell transcriptome data can be used to determine developmental lineage trajectories. Here the authors map single cell transcriptomes onto a differentiation trajectory defined by cell population transcriptomes and show that cell cycle regulators have a role in differentiation timing.

Na Sun
Xiaoming Yu
Jing-Dong J. Han
ResearchOpen Access30 Nov 2017
Nature Communications

Volume: 8, P: 1-12
A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing

Decreased autophagy is a hallmark of ageing, but its inter-tissue regulation is poorly understood. Here, Zhou et al. identify mir-83 in C. elegans, which is transported across tissues and suppresses autophagy, contributing to age-related decline.

Yifei Zhou
Xueqing Wang
Yidong Shen
ResearchOpen Access23 Oct 2019
Nature Communications

Volume: 10, P: 1-14
Base editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation

The role of DNA methylation in early embryo development has been difficult to determine due to the functional redundancy of DNA methyltransferases. Here they develop an efficient base editing system that enables one-step generation of Dnmt-null embryos and show that DNA methylation-related miRNA suppression may be involved in gastrulation.

Qing Li
Jiansen Lu
Jinsong Li
ResearchOpen Access22 May 2023
Nature Communications

Volume: 14, P: 1-19
Author Correction: Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4

Chengyang Huang
Yang Xiang
Charlie Degui Chen
Amendments and Corrections10 Jul 2025
Cell Research

Volume: 35, P: 779-780
Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation

Using time-lapse microscopy and transcriptome analysis of the post-implantation mouse embryo, Christodoulou et al. show that cavity fusion occurs through the formation and polarized resolution of multiple, multicellular three-dimensional rosettes.

Neophytos Christodoulou
Christos Kyprianou
Magdalena Zernicka-Goetz
Research15 Oct 2018
Nature Cell Biology

Volume: 20, P: 1278-1289
Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction

Fate-mapping and clonal analysis show that bronchioalveolar stem cells (BASCs) become activated and respond distinctly to different lung injuries and differentiate into multiple cell types. Single-cell RNA-seq analysis identifies new BASC markers.

Qiaozhen Liu
Kuo Liu
Bin Zhou
Research18 Feb 2019
Nature Genetics

Volume: 51, P: 728-738
Author Correction: Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction

Qiaozhen Liu
Kuo Liu
Bin Zhou
Amendments and Corrections07 Mar 2019
Nature Genetics

Volume: 51, P: 766
TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production

Attempts to treat Alzheimer's disease by targeting γ-secretase cleavage of APP into Aß have been unsuccessful, partially due to off-target effects. Here, the authors identify TRPC6 as a novel γ-secretase modulator, showing that it interacts with APP to regulate Aß levels while sparing Notch cleavage.

Junfeng Wang
Rui Lu
Yizheng Wang
ResearchOpen Access19 Nov 2015
Nature Communications

Volume: 6, P: 1-12
Genomic locus of lncRNA-Gm26793 forms an inter-chromosomal interaction with Cubn to ensure proper stem cell differentiation in vitro and in vivo

Zhiwen Liu
Xin Wan
Xianfa Yang
ResearchOpen Access03 Jun 2025
Cell Discovery

Volume: 11, P: 1-20
Author Correction: Formative pluripotent stem cells show features of epiblast cells poised for gastrulation

Xiaoxiao Wang
Yunlong Xiang
Lei Li
Amendments and CorrectionsOpen Access12 Jul 2022
Cell Research

Volume: 32, P: 866
Author Correction: Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII

Su Feng
Can Xing
Ke Tang
Amendments and CorrectionsOpen Access11 May 2018
Scientific Reports

Volume: 8, P: 1
Author Correction: Hormones induce the formation of luminal-derived basal cells in the mammary gland

Wenqian Song
Ran Wang
Yi Arial Zeng
Amendments and Corrections26 Feb 2019
Cell Research

Volume: 29, P: 338
FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers

Yunneng Tang
Guangwen Shu
Jianguo Song
Research07 Sept 2010
Cell Research

Volume: 21, P: 316-326
Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq

Geo-seq combines laser capture microdissection and single-cell RNA-seq technology to enable transcriptome analysis of small quantities of cells from defined geographical locations.

Jun Chen
Shengbao Suo
Naihe Jing
Protocols16 Feb 2017
Nature Protocols

Volume: 12, P: 566-580
Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures

Sozen et al. devise an approach to combine embryonic stem cells, trophoblast stem cells and extra-embryonic endoderm stem cells into self-assembling embryo-like structures, which recapitulate key hallmarks of gastrulation in vitro.

Berna Sozen
Gianluca Amadei
Magdalena Zernicka-Goetz
Research23 Jul 2018
Nature Cell Biology

Volume: 20, P: 979-989
Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies

Yuting Wang
Guangyi Dai
Haipeng Li
Research01 Apr 2020
Cell Research

Volume: 30, P: 408-420
Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs

Shuai Zhang
Xue Feng
Gang Wang
ResearchOpen Access15 Oct 2024
Cell Discovery

Volume: 10, P: 1-16
Formative pluripotent stem cells show features of epiblast cells poised for gastrulation

Xiaoxiao Wang
Yunlong Xiang
Lei Li
ResearchOpen Access19 Feb 2021
Cell Research

Volume: 31, P: 526-541
Hormones induce the formation of luminal-derived basal cells in the mammary gland

Wenqian Song
Ran Wang
Yi Arial Zeng
Research10 Jan 2019
Cell Research

Volume: 29, P: 206-220
Regulation of zebrafish dorsoventral patterning by phase separation of RNA-binding protein Rbm14

Yue Xiao
Jiehui Chen
Xueliang Zhu
ResearchOpen Access23 Jul 2019
Cell Discovery

Volume: 5, P: 1-17
Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development

Xianfa Yang
Boqiang Hu
Naihe Jing
Research07 Oct 2019
Cell Research

Volume: 29, P: 911-926
AF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation

Yunbo Qiao
Xiongjun Wang
Naihe Jing
ResearchOpen Access28 Jul 2015
Cell Discovery

Volume: 1, P: 1-19
Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII

Su Feng
Can Xing
Ke Tang
ResearchOpen Access13 Jul 2017
Scientific Reports

Volume: 7, P: 1-14
Mitochondrial replacement in macaque monkey offspring by first polar body transfer

Zhanyang Wang
Yuzhuo Li
Qiang Sun
Correspondence28 Jul 2020
Cell Research

Volume: 31, P: 233-236
Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages

Xianfa Yang
Boqiang Hu
Naihe Jing
Correspondence20 Feb 2018
Cell Research

Volume: 28, P: 593-596
CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development

Lingbo Wang
Min-Yin Li
Jinsong Li
Research21 Apr 2017
Cell Research

Volume: 27, P: 815-829
Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome

Chang Xie
Ya-Ping Zhang
Yan Yan
Research30 Aug 2016
Cell Research

Volume: 26, P: 1099-1111
AP2γ regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning

Yunbo Qiao
Yue Zhu
Naihe Jing
Research04 Sept 2012
Cell Research

Volume: 22, P: 1546-1561
rSac3, a novel Sac domain phosphoinositide phosphatase, promotes neurite outgrowth in PC12 cells

Yiyuan Yuan
Xiang Gao
Naihe Jing
Research01 Oct 2007
Cell Research

Volume: 17, P: 919-932
Visualization of bHLH transcription factor interactions in living mammalian cell nuclei and developing chicken neural tube by FRET

Chen Wang
Wei Bian
Naihe Jing
Research15 Jun 2006
Cell Research

Volume: 16, P: 585-598
Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4

Chengyang Huang
Yang Xiang
Charlie Degui Chen
Research19 Jan 2010
Cell Research

Volume: 20, P: 154-165

Search

Filter By:

Search

Quick links