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Showing 1–3 of 3 results
Advanced filters: Author: Naohiko Iguchi Clear advanced filters

  • Self-association of low-complexity protein sequences (LC domains) is important for polymer formation, but the mechanisms underlying cell recognition of LC domain polymers remain unclear. Here, authors show that zinc finger domains bind LC domains in a cross-β polymer-dependent manner.

    • Naohiko Iguchi
    • Noriyoshi Isozumi
    • Eiichiro Mori
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Nuclear import receptors (NIRs) regulate self-association of RNA-binding proteins as phase modifiers, while C9orf72-derived arginine-rich polydipeptides lead to aberrant phase transitions. Here the authors show in molecular basis how arginine-rich poly-dipeptides impede the ability of NIRs, particularly Kapβ2.

    • Hitoki Nanaura
    • Honoka Kawamukai
    • Eiichiro Mori
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12