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Showing 1–12 of 12 results
Advanced filters: Author: Naomi Moris Clear advanced filters

  • Researchers have used stem cells to create models that resemble human embryos at two weeks old, but bypass the earliest developmental stages — paving the way for studies that are not possible in human embryos.

    • Naomi Moris
    News & Views
    Nature
    Volume: 622, P: 469-470

  • Identical twins from a single embryo are formed in multiple species, albeit rarely. It is not clear how such twinning is suppressed during early development. Here they show that calcium signalling activity is propagated through the extraembryonic tissue to prevent ectopic primitive streak formation during gastrulation.

    • Hyung Chul Lee
    • Nidia M. M. Oliveira
    • Claudio D. Stern
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Cultures grown from small aggregates of mouse embryonic stem cells can be induced to organize spatial and temporal patterns of gene expression that parallel those of the early embryo, offering a potentially useful system for studying early development.

    • Leonardo Beccari
    • Naomi Moris
    • Alfonso Martinez Arias
    Research
    Nature
    Volume: 562, P: 272-276

  • Formal representations of Waddington's epigenetic landscape represent cell fate decisions as smooth, continuous events in which cells follow predetermined trajectories. Here, the authors provide an alternative interpretation and posit that fate decisions are discontinuous, stochastic events within cell lineages.

    • Naomi Moris
    • Cristina Pina
    • Alfonso Martinez Arias
    Reviews
    Nature Reviews Genetics
    Volume: 17, P: 693-703

  • A 3D model of human segmentation and somitogenesis derived from induced pluripotent stem cells captures the oscillatory dynamics of the segmentation clock as well as morphological and molecular features of the developing embryonic axis and tail.

    • Yoshihiro Yamanaka
    • Sofiane Hamidi
    • Cantas Alev
    Research
    Nature
    Volume: 614, P: 509-520

  • Single-cell RNA sequencing and spatial transcriptomics reveal that the somitogenesis clock is active in mouse gastruloids, which can be induced to generate somites with the correct rostral–caudal patterning.

    • Susanne C. van den Brink
    • Anna Alemany
    • Alexander van Oudenaarden
    Research
    Nature
    Volume: 582, P: 405-409

  • Pluripotent stem cells are being used to generate models of early embryogenesis that are promising for discovery and translational research. To be useful, these models require critical consideration of their level of efficiency and fidelity to natural embryos. Here we propose criteria with which to raise the standards of stem-cell-based embryo models of human embryogenesis.

    • Alfonso Martinez Arias
    • Nicolas Rivron
    • Aryeh Warmflash
    Comments & Opinion
    Nature Cell Biology
    Volume: 26, P: 1625-1628

  • Human embryology is flourishing thanks to an impetus provided by embryo models formed from stem cells. These scientific advances require meticulous experimental work and a refined ethical framework, but also sensible public communication. Securing public support is essential to achieve societal impact.

    • Nicolas C. Rivron
    • Alfonso Martinez-Arias
    • Kazuto Kato
    Comments & Opinion
    Nature Cell Biology
    Volume: 25, P: 1717-1719