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Showing 1–50 of 103 results

Advanced filters: Author: Naoya Kobayashi Clear advanced filters

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Simplified monitoring of sofosbuvir/velpatasvir in Japanese patients with chronic hepatitis C based on a retrospective analysis of a prospective multicenter cohort

Goki Suda
Masaru Baba
Naoya Sakamoto
ResearchOpen Access28 Nov 2025
Scientific Reports

Volume: 15, P: 1-7
Spectral Analysis of Polystyrene, Polypropylene, and Poly(methyl methacrylate) Polymers in TOF SIMS and XPS by MO Calculations Using the Model Oligomers

Kazunaka Endo
Naoya Kobayashi
Takahiro Hoshi
Research01 Oct 1996
Polymer Journal

Volume: 28, P: 901-910
Ionic Conductivity of Network Polymers from Poly(ethylene oxide) Containing Lithium Perchlorate

Masayoshi Watanabe
Satoshi Nagano
Naoya Ogata
Research01 Nov 1986
Polymer Journal

Volume: 18, P: 809-817
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Dislocation and oxygen-release driven delithiation in Li₂MnO₃

The delithiation process in lithium excess cathode material of Li₂MnO₃ has remained unclear. Here, the authors report that delithiation is governed by the climb motion of dislocations with the aid of oxygen-release, determined directly by atomic-resolution STEM imaging and spectroscopy.

Kei Nakayama
Ryo Ishikawa
Yuichi Ikuhara
ResearchOpen Access08 Sept 2020
Nature Communications

Volume: 11, P: 1-7
Lung adenocarcinoma cells respond differently to mechanical stress in 3D versus 2D environments

This study shows that lung adenocarcinoma cells respond differently to respiratory motion–mimicking mechanical stress in 3D compared with 2D environments, highlighting the need for 3D culture systems to better understand tumour mechanobiology.

Naoya Kitamura
Mayumi Iwatake
Tomoshi Tsuchiya
ResearchOpen Access11 Dec 2025
Communications Biology

Volume: 8, P: 1-14
Historical and future learning for the new era of multi-terawatt photovoltaics

Solar photovoltaics is entering a multi-terawatt era, driven by decades of cost, performance and reliability gains. In this Perspective Alberi et al. discuss the role of historical and future learning, highlighting the increasing importance of sustainability considerations.

Kirstin Alberi
I. Marius Peters
Andreas W. Bett
Reviews23 Dec 2025
Nature Energy

Volume: 11, P: 38-46
Design of complicated all-α protein structures

Here authors developed a computational method to design complicated all-α structures using typical helix–loop–helix motifs and canonical α-helices, and demonstrated the ability to create complicated all-α proteins.

Koya Sakuma
Naohiro Kobayashi
Nobuyasu Koga
ResearchOpen Access04 Jan 2024
Nature Structural & Molecular Biology

Volume: 31, P: 275-282
Plasma-Grafting of Polymers with Pendant Oligo(oxyethylene) Chains onto the Surface of a Polyaniline Electrode

Kenji Yamada
Akiko Ito
Tisato Kajiyama
Research01 Mar 2000
Polymer Journal

Volume: 32, P: 222-227
DNA–Lipid Hybrid Films Derived from Chiral Lipids

Naoya Ogata
Kanji Yamaoka
Research29 Jan 2008
Polymer Journal

Volume: 40, P: 186-191
Ionic Conductivity and Mobility of Poly(propylene oxide) Networks Dissolving Alkali Metal Thiocyanates

Masayoshi Watanabe
Kohei Sanui
Zentaro Ohtaki
Research01 Apr 1985
Polymer Journal

Volume: 17, P: 549-555
Artifact-free preparation of biological samples for SEM by optimized water freeze-drying

Hideki Ishida
Naoya Fukuda
Toshinobu Suzaki
ResearchOpen Access10 Dec 2025
Scientific Reports

Volume: 16, P: 1-12
Correction: Corrigendum: Reversal of mouse hepatic failure using an implanted liver-assist device containing ES cell–derived hepatocytes

Alejandro Soto-Gutiérrez
Naoya Kobayashi
Ira J Fox
Amendments and Corrections01 Feb 2007
Nature Biotechnology

Volume: 25, P: 254
Continuous visualization and validation of pain in critically ill patients using artificial intelligence: a retrospective observational study

Naoya Kobayashi
Kazuki Watanabe
Masanori Yamauchi
ResearchOpen Access14 Oct 2023
Scientific Reports

Volume: 13, P: 1-8
Analysis of Microcapsule Resin Using the X-Ray Photoelectron Nitrogen 1s Spectral Method

Chiaki Inoue
Naoya Kobayashi
Kazunaka Endo
Research01 Jun 1995
Polymer Journal

Volume: 27, P: 651-654
Temperature Dependence of Ionic Conductivity of Crosslinked Poly(propylene oxide) Films Dissolving Lithium Salts and Their Interfacial Charge Transfer Resistance in Contact with Lithium Electrodes

Masayoshi Watanabe
Kohei Sanui
Zentaro Ohtaki
Research01 Sept 1984
Polymer Journal

Volume: 16, P: 711-716
ctDNA-based molecular residual disease and survival in resectable colorectal cancer

In a large cohort with a 23-month median follow-up of the CIRCULATE-Japan GALAXY observational study, ctDNA-based detection of molecular residual disease was predictive of survival outcomes and benefit of adjuvant chemotherapy in patients with resectable colorectal cancer.

Yoshiaki Nakamura
Jun Watanabe
Eiji Oki
ResearchOpen Access16 Sept 2024
Nature Medicine

Volume: 30, P: 3272-3283
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Spectral Analysis of Eight Polymers in SIMS by MO Calculation. Prediction of Cleavage of Polymers and Structural Formula of the Positive-Ion Fragment

Kazunaka Endo
Takahiro Hoshi
Masahiro Kudo
Research01 May 1997
Polymer Journal

Volume: 29, P: 457-466
Reversal of mouse hepatic failure using an implanted liver-assist device containing ES cell–derived hepatocytes

Alejandro Soto-Gutiérrez
Naoya Kobayashi
Ira J Fox
Research05 Nov 2006
Nature Biotechnology

Volume: 24, P: 1412-1419
Estimation of the effect of atezolizumab plus bevacizumab on pulmonary arterial hypertension using computed tomography in HCC patients

Takayuki Kondo
Kisako Fujiwara
Naoya Kato
ResearchOpen Access17 Jul 2023
Scientific Reports

Volume: 13, P: 1-8
A diet-induced murine model for non-alcoholic fatty liver disease with obesity and insulin resistance that rapidly develops steatohepatitis and fibrosis

The presence of visceral obesity or type 2 diabetes mellitus is a major risk factor and potential therapeutic target for non-alcoholic fatty liver disease (NAFLD). A new murine NAFLD model established in this study had obesity and insulin resistance, and rapidly develop steatohepatitis and fibrosis. This model could be useful as preclinical models for drug development of NAFLD.

Takafumi Sakuma
Masato Nakamura
Naoya Kato
Research28 May 2022
Laboratory Investigation

Volume: 102, P: 1150-1157
microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity

Adaptive thermogenesis is regulated by central neuronal circuits. Here, the authors show that microRNA-33 in the brain contributes to the maintenance of brown adipose tissue thermogenesis and whole-body energy balance via enhanced sympathetic nerve tone, and regulating the expression of GABAa receptor subunits.

Takahiro Horie
Tetsushi Nakao
Koh Ono
ResearchOpen Access16 Feb 2021
Nature Communications

Volume: 12, P: 1-17
Exploratory analysis of gene aberrations and chemotherapy response: findings from a real-world database in Japan

Naoya Ishibashi
Takashi Kamatani
Sadakatsu Ikeda
ResearchOpen Access22 Dec 2025
British Journal of Cancer

P: 1-9
Trastuzumab deruxtecan in HER2-positive advanced gastric cancer: exploratory biomarker analysis of the randomized, phase 2 DESTINY-Gastric01 trial

Exploratory analyses of the DESTINY-Gastric01 trial show that baseline HER2-associated biomarkers in circulating tumor DNA or tissue samples were associated with therapeutic response in patients with HER2-positive tumors, and these analyses identify potential drivers of resistance.

Kohei Shitara
Yung-Jue Bang
Kensei Yamaguchi
ResearchOpen Access14 May 2024
Nature Medicine

Volume: 30, P: 1933-1942
Structural and thermodynamic insights into antibody light chain tetramer formation through 3D domain swapping

Atomic-level structural examinations of antibody light chain aggregates are sparse. Here, the authors find an antibody light chain that maintains an equilibrium between monomeric and tetrameric states and show with its 3D structure that it engages in 3D domain swapping within its variable region.

Takahiro Sakai
Tsuyoshi Mashima
Shun Hirota
ResearchOpen Access08 Dec 2023
Nature Communications

Volume: 14, P: 1-12
Neutron Reflectometry on Interfacial Structures of the Thin Films of Polymer and Lipid

Naoya Torikai
Norifumi L Yamada
Yushu Matsushita
Reviews02 Nov 2007
Polymer Journal

Volume: 39, P: 1238-1246
Optical Resolution of Racemic Amino Acids through DNA-Poly(4-vinylbenzyl)trimethylammonium Polyion Complex Membranes

Masakazu Yoshikawa
Motokazu Maruhashi
Naoya Ogata
Research02 Oct 2007
Polymer Journal

Volume: 39, P: 1193-1198
A new cell-permeable peptide allows successful allogeneic islet transplantation in mice

Hirofumi Noguchi
Masayuki Matsushita
Hideki Matsui
Research08 Feb 2004
Nature Medicine

Volume: 10, P: 305-309
Ferromagnetic dislocations in antiferromagnetic NiO

Magnetic force microscopy imaging reveals that individual dislocations in antiferromagnetic NiO crystals show ferromagnetic behaviour originating from the local atomic-scale structure.

Issei Sugiyama
Naoya Shibata
Yuichi Ikuhara
Research24 Mar 2013
Nature Nanotechnology

Volume: 8, P: 266-270
Tcf21 modulates fibroblast activation and promotes cardiac fibrosis after injury via Pdgfrb signaling

Yusuke Baba
Yoshiro Maezawa
Koutaro Yokote
ResearchOpen Access02 Aug 2025
Scientific Reports

Volume: 15, P: 1-15
Hydrogen-generating Si-based agent protects against skin flap ischemia–reperfusion injury in rats

Naoya Otani
Koichi Tomita
Tateki Kubo
ResearchOpen Access13 Apr 2022
Scientific Reports

Volume: 12, P: 1-8
Efficacy of second-line chemotherapy in patients with pulmonary large cell neuroendocrine carcinoma

Yuko Iida
Kazushige Wakuda
Toshiaki Takahashi
ResearchOpen Access01 Apr 2024
Scientific Reports

Volume: 14, P: 1-10
Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy

Targeting the inhibitory receptors (IRs) LAG-3, TIM-3 and TIGIT is a promising immune-oncology approach and the identification of biomarkers of response is crucial. Here, the authors apply automated single-cell count for these IRs in human renal cell carcinoma and investigate the immunogenomic landscape of the disease.

Kimiharu Takamatsu
Nobuyuki Tanaka
Mototsugu Oya
ResearchOpen Access20 Sept 2021
Nature Communications

Volume: 12, P: 1-12
The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma

Hiroaki Kanzaki
Tetsuhiro Chiba
Naoya Kato
ResearchOpen Access05 Mar 2021
Scientific Reports

Volume: 11, P: 1-12
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies

Checkpoint blockade is effective in only a subset of patients; therefore, biomarkers that can predict efficacy would be clinically highly valuable. Nishkawa and colleagues develop a biomarker based on PD-1 positivity of effector and regulatory T cells in the tumor microenvironment that accurately predicts the effectiveness of checkpoint blockade in patients.

Shogo Kumagai
Yosuke Togashi
Hiroyoshi Nishikawa
Research31 Aug 2020
Nature Immunology

Volume: 21, P: 1346-1358
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Semi-automated tracking of pain in critical care patients using artificial intelligence: a retrospective observational study

Naoya Kobayashi
Takuya Shiga
Masanori Yamauchi
ResearchOpen Access04 Mar 2021
Scientific Reports

Volume: 11, P: 1-7
Modulation of circadian clock by crude drug extracts used in Japanese Kampo medicine

Manhui Zhang
Kohei Kobayashi
Takashi Yoshimura
ResearchOpen Access26 Oct 2021
Scientific Reports

Volume: 11, P: 1-9
Modified cell-permeable JNK inhibitors efficiently prevents islet apoptosis and improves the outcome of islet transplantation

Hirofumi Noguchi
Chika Miyagi-Shiohira
Masami Watanabe
ResearchOpen Access23 Jul 2018
Scientific Reports

Volume: 8, P: 1-9
Development and validation of predictive model for emesis in cervical cancer patients receiving concurrent chemoradiotherapy based on multi-institutional retrospective study

Kensuke Yoshida
Hajime Morita
Munetoshi Sugiura
ResearchOpen Access27 Oct 2025
Scientific Reports

Volume: 15, P: 1-9
Bimetallic Metal-Organic Frameworks for Controlled Catalytic Graphitization of Nanoporous Carbons

Jing Tang
Rahul R. Salunkhe
Yusuke Yamauchi
ResearchOpen Access29 Jul 2016
Scientific Reports

Volume: 6, P: 1-8
Tumour lineage-homing cell-penetrating peptides as anticancer molecular delivery systems

Cell-penetrating peptides can be used to deliver nucleic acids and proteins to cells, however they lack selectivity. In this study, cell-penetrating peptides are generated that can selectively target tumour cells of different cellular origins and these may be useful in the treatment of cancer.

Eisaku Kondo
Ken Saito
Masayuki Matsushita
Research17 Jul 2012
Nature Communications

Volume: 3, P: 1-13
A human β-cell line for transplantation therapy to control type 1 diabetes

Michiki Narushima
Naoya Kobayashi
Ji-Won Yoon
Research25 Sept 2005
Nature Biotechnology

Volume: 23, P: 1274-1282
Drug Release OFF Behavior and Deswelling Kinetics of Thermo-Responsive IPNs Composed of Poly(acrylamide-co-butyl methacrylate) and Poly(acrylic acid)

Hiroki Katono
Kohei Sanui
Yasuhisa Sakurai
Research01 Oct 1991
Polymer Journal

Volume: 23, P: 1179-1189
Unnarmicins A and C, New Antibacterial Depsipeptides Produced by Marine Bacterium Photobacterium sp. MBIC06485

Naoya Oku
Kazutaka Kawabata
Yoshikazu Shizuri
Research01 Jan 2008
The Journal of Antibiotics

Volume: 61, P: 11-17

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