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Showing 1–3 of 3 results
Advanced filters: Author: Narayan Karanth Clear advanced filters

  • Patients with metastatic cancers of unknown primary (CUP) are currently unable to gain access to drugs through standard of care or clinical trials. Here, the authors perform whole-genome and transcriptome sequencing (WGTS) on 72 patients with CUP and demonstrate the feasibility of using WGTS to determine the specific cancer types of CUP, thereby clinically benefiting patients with CUP.

    • Richard J. Rebello
    • Atara Posner
    • Richard W. Tothill
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • As presented at the ESMO Congress 2025: Results of the phase 2/3 AGITG DYNAMIC-III trial show that de-escalated chemotherapy based on ctDNA-negative status in patients with stage III colon cancer did not meet non-inferiority for 3-year recurrence-free survival when compared to standard of care, although it enables better informed treatment decisions.

    • Jeanne Tie
    • Yuxuan Wang
    • Petr Kavan
    Research
    Nature Medicine
    Volume: 31, P: 4291-4300