DNA affinity purification and sequencing (DAP-seq) allows genome-scale studies of transcription factor (TF)-binding sites with high reproducibility. Here, Lax et al. use this technique to characterize 58 TFs encoded by genes regulated by adenine methylation, and provide insights into the regulatory mechanisms of gene expression in an opportunistic pathogenic fungus.
- Carlos Lax
- Leo A. Baumgart
- Victoriano Garre