Activation of cytosolic nucleic acid sensors in tumor cells is an important early step for initiating antitumor immunity, but the mechanisms controlling their activity are not fully understood. Using an in vivo CRISPR screen, CDK10 is now revealed as a cancer cell-intrinsic driver of immune evasion that limits production of immunostimulatory nucleic acids.
- Natalie S. Firmino
- Nathaniel R. West
