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Showing 1–14 of 14 results
Advanced filters: Author: Natasja M. S. de Groot Clear advanced filters

  • The chimeric candidate Zika virus vaccine YF-ZIK has been previously shown to confer protection in mice after a single dose regimen. Here the authors further characterise the response to YF-ZIK and show induction of immunity and protection in non-human primates.

    • Ji Ma
    • Bert Malengier-Devlies
    • Kai Dallmeier
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

    • Loïc Yengo
    • Sailaja Vedantam
    • Joel N. Hirschhorn
    ResearchOpen Access
    Nature
    Volume: 610, P: 704-712

  • Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find that these variants cluster in pathways involved in growth and together explain one-fifth of the heritability for this trait.

    • Andrew R Wood
    • Tonu Esko
    • Timothy M Frayling
    Research
    Nature Genetics
    Volume: 46, P: 1173-1186

  • Data from over 700,000 individuals reveal the identity of 83 sequence variants that affect human height, implicating new candidate genes and pathways as being involved in growth.

    • Eirini Marouli
    • Mariaelisa Graff
    • Guillaume Lettre
    Research
    Nature
    Volume: 542, P: 186-190

  • Muscle weakness has been associated with morbidity and mortality in older people. Here, the authors have investigated this trait further by performing a genome-wide meta-analysis of grip strength and Mendelian randomization to discover causal relationships between muscle weakness and other diseases.

    • Garan Jones
    • Katerina Trajanoska
    • Luke C. Pilling
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Atrial fibrillation (AF) is accompanied by a detrimental loss of functional cardiomyocytes. Here, Zhang et al. show that AF-induced cardiomyocyte dysfunction is a consequence of DNA damage-mediated PARP1 activation, which leads to depletion of NAD+ and further oxidative stress and DNA damage, and identify PARP1 inhibition as a potential therapeutic strategy in the treatment of AF.

    • Deli Zhang
    • Xu Hu
    • Bianca J. J. M. Brundel
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Vitamin D deficiency is associated with multiple human pathologic conditions. In a genome-wide association study of 79,366 individuals, Jiang et al. replicate four and identify two new genetic loci for serum levels of 25-hydroxyvitamin D and find evidence for a shared genetic basis with autoimmune diseases.

    • Xia Jiang
    • Paul F. O’Reilly
    • Douglas P. Kiel
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specific bacterial genetic variation associated with susceptibility.

    • John A. Lees
    • Bart Ferwerda
    • Diederik van de Beek
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Human population genomic studies, including whole‐genome sequencing, were undertaken to identify determinants of bone mineral density (BMD), a major predictor of osteoporotic fractures. Non‐coding variants with large effects on BMD and fractures were identified near the EN1 locus and mouse studies confirmed this gene has an important role in skeletal biology.

    • Hou‐Feng Zheng
    • Vincenzo Forgetta
    • J. Brent Richards
    Research
    Nature
    Volume: 526, P: 112-117

  • Atrial fibrillation (AF) is the most common cardiac arrhythmia and is increasing in prevalence as populations age. This Primer provides an overview of AF epidemiology, the mechanisms underlying electropathology in AF, and the diagnostic approaches and treatments, and highlights important directions to improve understanding and management of AF in co-creation with patients.

    • Bianca J. J. M. Brundel
    • Xun Ai
    • Natasja M. S. de Groot
    Reviews
    Nature Reviews Disease Primers
    Volume: 8, P: 1-23

  • Katerina Trajanoska et al. report a genome-wide association study of self-reported falls in UK Biobank participants. They identify three novel fall-associated loci and find that risk of falling shows patterns of polygenic inheritance and a SNP-based heritability of 2.7%.

    • Katerina Trajanoska
    • Lotta J. Seppala
    • Fernando Rivadeneira
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-10