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HEXIM1 inter-monomer autoinhibition governs 7SK RNA binding specificity and P-TEFb inactivation

Hexim regulates transcription by sequestering kinase P-TEFb in the 7SK RNP. Here, the authors show that Hexim autoinhibition dictates its specificity for 7SK RNA and safeguards against premature P-TEFb inactivation, coupling transcriptional control to RNP assembly.

Yuan Yang
Maria Grazia Murrali
Juli Feigon
ResearchOpen Access15 Jan 2026
Nature Communications

P: 1-16

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HEXIM1 inter-monomer autoinhibition governs 7SK RNA binding specificity and P-TEFb inactivation

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