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Advanced filters: Author: Nestor F. Esnaola Clear advanced filters

T cells engineered against Dickkopf-1-A2 complex can be used to treat HLA-A2⁺ solid and hematologic cancers

Chimeric antigen receptor (CAR)-T cell therapy has shown promise but remains limited against solid tumors. This study reports that DKK1-A2 CAR-T cells selectively target HLA-A2- and DKK1-positive tumors, suggesting their therapeutic potential in treating human cancers.

Yufei Zhang
Wei Xiong
Qing Yi
ResearchOpen Access16 Feb 2026
Nature Communications

P: 1-16
Comparative molecular profiling of pancreatic ductal adenocarcinoma of the head versus body and tail

Maen Abdelrahim
Abdullah Esmail
Benjamin A. Weinberg
ResearchOpen Access06 Apr 2024
npj Precision Oncology

Volume: 8, P: 1-8

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T cells engineered against Dickkopf-1-A2 complex can be used to treat HLA-A2+ solid and hematologic cancers

Comparative molecular profiling of pancreatic ductal adenocarcinoma of the head versus body and tail

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T cells engineered against Dickkopf-1-A2 complex can be used to treat HLA-A2⁺ solid and hematologic cancers