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Showing 1–6 of 6 results
Advanced filters: Author: Nestor Falcon Clear advanced filters

  • Including data from 1,047 patients across 19 inflammatory diseases, a new atlas presents a comprehensive model of inflammation in circulating immune cells.

    • Laura Jiménez-Gracia
    • Davide Maspero
    • Holger Heyn
    ResearchOpen Access
    Nature Medicine
    P: 1-12

  • X-chromosome inactivation (XCI) contributes to sex bias in T cell immunity, but data on profiling XCI during human T cell development is still lacking. Here, the authors leverage allele-specific expression, sex-biased gene expression and DNA methylation data on human pediatric thymocytes to find surprisingly stable XCI during thymocyte differentiation.

    • Björn Gylemo
    • Maike Bensberg
    • Colm E. Nestor
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • The structure of the assembly-competent 5S RNP was elucidated by cryo-EM. These findings provide molecular insight into how this module incorporates into the nascent pre-60S ribosome and how it can affect the MDM2–p53 pathway in human cells.

    • Nestor Miguel Castillo Duque de Estrada
    • Matthias Thoms
    • Ed Hurt
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 1119-1131

  • Early embryonic cell fate and lineage specification is tightly regulated in the preimplantation mammalian embryo. Here, the authors quantitatively examine the ratio of epiblast to primitive endoderm lineages in the blastocyst and show composition of the inner cell mass is conserved, independent of its size.

    • Néstor Saiz
    • Kiah M. Williams
    • Anna-Katerina Hadjantonakis
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • The biosynthetic pathway of strychnine, brucine and diaboline is described, and the biosynthesis of these complex, pharmacologically active compounds has been successfully recapitulated in Nicotiana benthamiana from an upstream intermediate.

    • Benke Hong
    • Dagny Grzech
    • Sarah E. O’Connor
    ResearchOpen Access
    Nature
    Volume: 607, P: 617-622