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Showing 1–12 of 12 results
Advanced filters: Author: Nicholas J. P. Ryba Clear advanced filters

  • Functional imaging and multiplexed in situ hybridization were combined to investigate how trigeminal neurons encode heat and mechanical stimuli, revealing distinct cellular mechanisms for continuing pain, heat hypersensitivity and tactile allodynia during inflammation.

    • Nima Ghitani
    • Lars J. von Buchholtz
    • Alexander T. Chesler
    ResearchOpen Access
    Nature
    Volume: 642, P: 1016-1023

  • High concentrations of salt activate sour- and bitter-taste-sensing cells in the tongues of mice, and genetic silencing of these pathways abolishes behavioural aversion to concentrated salt; this ‘co-opting’ of the two primary aversive taste pathways (sour and bitter) may have evolved so that high salt levels reliably trigger behavioural rejection.

    • Yuki Oka
    • Matthew Butnaru
    • Charles S. Zuker
    Research
    Nature
    Volume: 494, P: 472-475

  • Using two-photon microendoscopy and genetically encoded calcium indicators the tuning properties of the first neural station of the gustatory system are explored; results reveal that ganglion neurons are matched to specific taste receptor cells, supporting a labelled line model of information transfer in the taste system.

    • Robert P. J. Barretto
    • Sarah Gillis-Smith
    • Charles S. Zuker
    Research
    Nature
    Volume: 517, P: 373-376

  • Mammals are repelled by large concentrations of salts but attracted to low concentrations of sodium. In mice, the latter behaviour can be blocked by the ion channel inhibitor amiloride. Here, mice have been produced lacking the drug's target sodium channel, ENaC, specifically in taste receptor neurons. It is confirmed that sodium sensing, like the four other taste modalities (sweet, sour, bitter and umami), is mediated by a dedicated 'labelled line'.

    • Jayaram Chandrashekar
    • Christina Kuhn
    • Charles S. Zuker
    Research
    Nature
    Volume: 464, P: 297-301

  • Activation of the sweet and bitter cortical fields in awake mice evokes predetermined behavioural programs, independent of learning and experience, illustrating the hardwired and innate nature of the sense of taste.

    • Yueqing Peng
    • Sarah Gillis-Smith
    • Charles S. Zuker
    Research
    Nature
    Volume: 527, P: 512-515

  • The identity and hedonic value of tastes are encoded in distinct neural substrates; in mice, the amygdala is necessary and sufficient to drive valence-specific behaviours in response to bitter or sweet taste stimuli, and the cortex can independently represent taste identity.

    • Li Wang
    • Sarah Gillis-Smith
    • Charles S. Zuker
    Research
    Nature
    Volume: 558, P: 127-131

  • Taste-receptor cells use distinct semaphorins to guide wiring of the peripheral taste system; targeted ectopic expression of SEMA3A or SEMA7A leads to bitter neurons responding to sweet tastes or sweet neurons responding to bitter tastes.

    • Hojoon Lee
    • Lindsey J. Macpherson
    • Nicholas J. P. Ryba
    Research
    Nature
    Volume: 548, P: 330-333