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Showing 1–4 of 4 results
Advanced filters: Author: Nicholas Shukeir Clear advanced filters

  • Histone H3K9 methylation (H3K9me) states define repressed chromatin in eukaryotic cells. Here the authors reveal complete loss of all H3K9me in mammalian cells through successive deletion of H3K9 methyltransferase genes that results in the dissolution of heterochromatin and the derepression of nearly all repeat families.

    • Thomas Montavon
    • Nicholas Shukeir
    • Thomas Jenuwein
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • The mechanisms that initiate heterochromatin formation and maintain its distinction from euchromatin have remained elusive. However, a new study reveals a pathway in which transcriptional repression of pericentric repeats by sequence-specific transcription factors is essential for the integrity of heterochromatin, thereby considerably expanding the role of transcription factors beyond euchromatic gene regulation.

    • Aydan Bulut-Karslioglu
    • Valentina Perrera
    • Thomas Jenuwein
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 1023-1030