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Showing 1–7 of 7 results
Advanced filters: Author: Nick van den Broeck Clear advanced filters

  • JNJ-9676—a small-molecule inhibitor targeting coronavirus M protein that shows excellent efficacy in Syrian golden hamster models—binds to and stabilizes the M protein dimer in an altered conformational state between its long and short forms, preventing the release of infectious virus.

    • Ellen Van Damme
    • Pravien Abeywickrema
    • Marnix Van Loock
    ResearchOpen Access
    Nature
    Volume: 640, P: 506-513

  • Here the authors provide a detailed virological analysis of thirteen postmortem COVID-19 cases, including presence of replication-competent SARS-CoV-2 in extrapulmonary organs and tissue-specific patterns of SARS-CoV-2 genome diversity of an immunocompromised patient.

    • Jolien Van Cleemput
    • Willem van Snippenberg
    • Linos Vandekerckhove
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • In many European countries, more than half of the SARS-CoV-2 lineages circulating in late summer 2020 resulted from new introductions, highlighting the threat of viral dissemination when restrictions are lifted.

    • Philippe Lemey
    • Nick Ruktanonchai
    • Simon Dellicour
    Research
    Nature
    Volume: 595, P: 713-717

  • Structural insights into SARS and MERS coronavirus membrane protein reveals differences and conserved sites of an inhibitor binding pocket, aiding in the design of broad-spectrum and specific antivirals.

    • Mandeep Kaur Mann
    • Yanting Yin
    • Pravien Abeywickrema
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-10

  • African trypanosomes can reduce their requirement for tsetse fly transmission, allowing an expanded geographical range. Here, molecular analyses of field and laboratory selected lines has identified adaptions for the parasite’s simplified life cycle.

    • Guy R. Oldrieve
    • Frank Venter
    • Keith R. Matthews
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14