Nature Search

BioContextAI is a community hub for agentic biomedical systems

Malte Kuehl
Darius P. Schaub
Victor G. Puelles
Correspondence06 Nov 2025
Nature Biotechnology

Volume: 43, P: 1755-1757
Pathology-oriented multiplexing enables integrative disease mapping

Pathology-oriented multiplexing (PathoPlex) represents a framework for widespread access to multiplexed imaging and computational image analysis of clinical specimens at a relatively high throughput and subcellular resolution.

Malte Kuehl
Yusuke Okabayashi
Victor G. Puelles
ResearchOpen Access18 Jul 2025
Nature

Volume: 644, P: 516-526
C-terminal UBA domains protect ubiquitin receptors by preventing initiation of protein degradation

Rad23 and Dsk2 bind polyubiquitylated proteins and escort them to the proteasome for destruction. In this study, Heinenet al.investigate the molecular mechanisms that protect the C-terminal UBA domains of Rad23 and Dsk2 from proteasomal destruction.

Christian Heinen
Klàra Ács
Nico P. Dantuma
ResearchOpen Access08 Feb 2011
Nature Communications

Volume: 2, P: 1-9
Ketosis in patients undergoing medically supervised therapeutic fasting—results from an observational trial

Martina-Annette Thaele-Franz
Nico Steckhan
Rainer Stange
Research01 Sept 2020
European Journal of Clinical Nutrition

Volume: 74, P: 43-47
Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs

Synthetic embryo models have arisen as an approach to probe early development in vitro, facilitating the study of difficult to access stages. Here the authors present a simple system for generating embryo-like structures that resemble peri-implantation mouse embryos.

Jan Langkabel
Arik Horne
Hubert Schorle
ResearchOpen Access16 Dec 2021
Nature Communications

Volume: 12, P: 1-18
Identification of inulin-responsive bacteria in the gut microbiota via multi-modal activity-based sorting

Here, Riva et al. employ a multi-modal approach to identify gut microbes stimulated by the popular dietary supplement inulin and reveal that inulin binding and metabolic stimulation are widespread in the microbiome, making the framework a suitable way to study key microbes that perform specific functions in the microbiome.

Alessandra Riva
Hamid Rasoulimehrabani
David Berry
ResearchOpen Access14 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Combination therapy with the anti-HIV-1 monoclonal antibodies 3BNC117 and 10-1074 maintains long-term suppression in the absence of antiretroviral therapy in individuals with antibody-sensitive viral reservoirs.

Pilar Mendoza
Henning Gruell
Michel C. Nussenzweig
Research26 Sept 2018
Nature

Volume: 561, P: 479-484
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

This genome-wide study of age at first sexual intercourse and first birth identifies 371 signals driven by reproductive biology, externalising behaviour and environmental effects, with later onset associated with lower incidence of some diseases.

Melinda C. Mills
Felix C. Tropf
Felix R. Day
Research01 Jul 2021
Nature Human Behaviour

Volume: 5, P: 1717-1730
Ecosystem restoration strengthens pollination network resilience and function

Removal of invasive exotic shrubs from mountaintop communities increased the number of pollinators and positively altered pollinator behaviour, which enhanced native fruit production, indicating that the degradation of ecosystem functions is partly reversible.

Christopher N. Kaiser-Bunbury
James Mougal
Nico Blüthgen
Research30 Jan 2017
Nature

Volume: 542, P: 223-227
High diversity stabilizes the thermal resilience of pollinator communities in intensively managed grasslands

How variation in species responses to climate may influence the resilience of ecological communities to environmental change is not fully understood. Here, the authors characterize the thermal niches of insect pollinator communities and show that resilience increases along a gradient of land-use intensity.

Sara Kühsel
Nico Blüthgen
ResearchOpen Access10 Aug 2015
Nature Communications

Volume: 6, P: 1-10
Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

Many genetic variants identified in genome-wide association studies are associated with gene expression. Here, Porcu et al. propose a transcriptome-wide summary statistics-based Mendelian randomization approach (TWMR) that, applied to 43 human traits, uncovers hundreds of previously unreported gene–trait associations.

Eleonora Porcu
Sina Rüeger
Zoltán Kutalik
ResearchOpen Access24 Jul 2019
Nature Communications

Volume: 10, P: 1-12
Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

Florian Klein and colleagues report that treating viremic HIV-1-infected individuals with the broadly neutralizing antibody 10-1074 reduced virus levels in blood, but antibody-resistant virus did emerge.

Marina Caskey
Till Schoofs
Florian Klein
Research16 Jan 2017
Nature Medicine

Volume: 23, P: 185-191
Using mobile phone data to map evacuation and displacement: a case study of the central Italy earthquake

Francesca Giardini
Natalia Selini Hadjidimitriou
Francesca Pancotto
ResearchOpen Access14 Dec 2023
Scientific Reports

Volume: 13, P: 1-19
Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

Combination of two broadly neutralizing antibodies is effective in reducing HIV-1 viremia and in limiting the emergence of resistant viral variants in individuals harboring antibody-sensitive viruses.

Yotam Bar-On
Henning Gruell
Michel C. Nussenzweig
Research26 Sept 2018
Nature Medicine

Volume: 24, P: 1701-1707
Publisher Correction: Identification of 371 genetic variants for age at first sex and birth linked to externalising behavior

Melinda C. Mills
Felix C. Tropf
Felix R. Day
Amendments and Corrections28 Jul 2021
Nature Human Behaviour

Volume: 5, P: 1111
Conceptualizing soil fauna effects on labile and stabilized soil organic matter

In their review, Angst et al. conceptualize how the ecological strategies of a multitude of soil faunal taxa can influence the formation of particulate and mineral-associated organic matter. The authors highlight research gaps and ways forward.

Gerrit Angst
Anton Potapov
Nico Eisenhauer
ReviewsOpen Access17 Jun 2024
Nature Communications

Volume: 15, P: 1-16
Using AI and Gd-EOB-DTPA-enhanced MR imaging to assess liver function, comparing the MELIF score with the ALBI score

Carolina Río Bártulos
Karin Senk
Philipp Wiggermann
ResearchOpen Access12 Aug 2023
Scientific Reports

Volume: 13, P: 1-9
A comparison of pediatric inflammatory multisystem syndrome temporarily-associated with SARS-CoV-2 and Kawasaki disease

Markus Hufnagel
Jakob Armann
Ulrich Zügge
ResearchOpen Access20 Jan 2023
Scientific Reports

Volume: 13, P: 1-14

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