Nature Search

Evaluation of commercially available glucagon receptor antibodies and glucagon receptor expression

An assessment of all commercially available antibodies targeting the G-protein-coupled receptor (GPCR), glucagon receptor (GCGR) is used to highlight the most reliable antibody in immunostaining, including an antibody-independent verification.

Anna Billeschou Bomholt
Christian Dall Johansen
Nicolai Jacob Wewer Albrechtsen
ResearchOpen Access22 Nov 2022
Communications Biology

Volume: 5, P: 1-13
The diagnostic potential of proteomics and machine learning in Lyme neuroborreliosis

Researchers incorporate mass spectrometry-based proteomics and machine learning to assess the potential of a less invasive diagnostic approach for Lyme neuroborreliosis, a common nervous system infection.

Annelaura Bach Nielsen
Lasse Fjordside
Nicolai J. Wewer Albrechtsen
ResearchOpen Access27 Oct 2025
Nature Communications

Volume: 16, P: 1-13
An adaptive, continuous-learning framework for clinical decision-making from proteome-wide biofluid data

Discovery proteomics offers deep insights but is currently not applied clinically in diagnostics. Here, the authors present ADAPT-MS, a flexible machine learning framework that enables fast, personalized diagnostic and prognostic decisions directly from proteome-wide data.

Johannes B. Müller-Reif
Vincent Albrecht
Matthias Mann
ResearchOpen Access27 Jan 2026
Nature Communications

Volume: 17, P: 1-10
Proteomic profiling reveals diagnostic signatures and pathogenic insights in multisystem inflammatory syndrome in children

Proteomic profiling reveals diagnostic signatures and pathogenic insights in multisystem inflammatory syndrome in children.

Ulrikka Nygaard
Annelaura Bach Nielsen
Nicolai J. Wewer Albrechtsen
ResearchOpen Access05 Jun 2024
Communications Biology

Volume: 7, P: 1-10
Prevention of type 2 diabetes through prediabetes remission without weight loss

A post hoc analysis of a multicentre, randomised trial showed that prediabetes remission is possible without total weight loss—providing weight is distributed to subcutaneous deposits as opposed to visceral ones.

Arvid Sandforth
Elsa Vazquez Arreola
Reiner Jumpertz von Schwartzenberg
ResearchOpen Access29 Sept 2025
Nature Medicine

Volume: 31, P: 3330-3340
Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men

Dietary protein restriction in healthy, lean men elicits an increased energy intake to maintain body weight, which is driven, at least in part, by FGF21-mediated alterations to adipose tissue mitochondria.

Trine S. Nicolaisen
Aslak E. Lyster
Bente Kiens
ResearchOpen Access06 Mar 2025
Nature Metabolism

Volume: 7, P: 602-616
Data sharing restrictions are hampering precision health in the European Union

Cristina Legido-Quigley
Nicolai J. Wewer Albrechtsen
Karolina Sulek
Correspondence17 Jan 2025
Nature Medicine

Volume: 31, P: 360-361
A knowledge graph to interpret clinical proteomics data

A knowledge graph platform integrates proteomics with other omics data and biomedical databases.

Alberto Santos
Ana R. Colaço
Matthias Mann
ResearchOpen Access31 Jan 2022
Nature Biotechnology

Volume: 40, P: 692-702
FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism

Insulin signaling represses Forkhead transcription factor FoxO activity, which contributes to organismal metabolism. Here, the authors use proteomics to identify positively regulated insulin signaling targets FoxK1/K2 and demonstrate their role in lipid metabolism and mitochondrial regulation.

Masaji Sakaguchi
Weikang Cai
C. Ronald Kahn
ResearchOpen Access05 Apr 2019
Nature Communications

Volume: 10, P: 1-17
Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine

Ida M. Modvig
Daniel B. Andersen
Jens J. Holst
ResearchOpen Access03 Feb 2020
International Journal of Obesity

Volume: 44, P: 1859-1871
Four weeks treatment with the GLP-1 receptor analogue liraglutide lowers liver fat and concomitantly circulating glucagon in individuals with overweight

Maria S. Svane
Helle H. Johannesen
Nicolai J. Wewer Albrechtsen
Research18 Aug 2022
International Journal of Obesity

Volume: 46, P: 2058-2062
Islet hormones at the intersection of glucose and amino acid metabolism

This Review discusses how levels of glucose, amino acids and lipids influence islet hormone secretion. The authors also discuss how crosstalk between α-cells, β-cells and δ-cells regulates islet hormone secretion and how islet hormones control the metabolism of different nutrients.

Phillip J. White
Nicolai J. Wewer Albrechtsen
Jonathan E. Campbell
Reviews07 Mar 2025
Nature Reviews Endocrinology

Volume: 21, P: 397-412
Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy

Aleksander Eiken
Stefan Fuglsang
Carsten Dirksen
Research21 Apr 2020
International Journal of Obesity

Volume: 44, P: 1872-1883
Predictors of weight loss after bariatric surgery—a cross-disciplinary approach combining physiological, social, and psychological measures

Mette S. Nielsen
Bodil Just Christensen
Anders Sjödin
Research23 Apr 2020
International Journal of Obesity

Volume: 44, P: 2291-2302

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