Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–12 of 12 results
Advanced filters: Author: Nicolas C. Rivron Clear advanced filters

  • The authors provide a suite of in vitro protocols through which mouse and human pluripotent stem cells, mouse blastocysts and human blastoids can be reversibly induced to enter a diapause-like dormant state via pharmacological inhibition of mTOR

    • Dhanur P. Iyer
    • Heidar Heidari Khoei
    • Aydan Bulut-Karslioglu
    Protocols
    Nature Protocols
    P: 1-28

  • Trophoblast and embryonic stem cells interact in vitro to form structures that resemble early blastocysts, and the embryo provides signals that drive early trophectoderm development and implantation.

    • Nicolas C. Rivron
    • Javier Frias-Aldeguer
    • Niels Geijsen
    Research
    Nature
    Volume: 557, P: 106-111

  • Blastoids derived from naive PXGL-cultured human pluripotent stem cells in which Hippo, TGF-β and ERK pathways are inhibited closely recapitulate aspects of blastocyst development, form cells resembling blastocyst-stage cells and thus provide a model system for implantation and development studies.

    • Harunobu Kagawa
    • Alok Javali
    • Nicolas Rivron
    ResearchOpen Access
    Nature
    Volume: 601, P: 600-605

  • While the core regulators involved in maintenance of naïve and formative pluripotency have been described, less is known about the regulation of the transition between the two states. Here they show that FoxO transcription factors mediate the naïve to formative pluripotency transition and are regulated via AKT phosphorylation.

    • Laura Santini
    • Saskia Kowald
    • Martin Leeb
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Human embryology is flourishing thanks to an impetus provided by embryo models formed from stem cells. These scientific advances require meticulous experimental work and a refined ethical framework, but also sensible public communication. Securing public support is essential to achieve societal impact.

    • Nicolas C. Rivron
    • Alfonso Martinez-Arias
    • Kazuto Kato
    Comments & Opinion
    Nature Cell Biology
    Volume: 25, P: 1717-1719

  • Authentic hypoblast cells created from naive human pluripotent stem cells (hPSCs) spontaneously assemble with naive hPSCs to form a three-dimensional bilaminar structure (bilaminoids) with a pro-amniotic-like cavity.

    • Takumi Okubo
    • Nicolas Rivron
    • Yasuhiro Takashima
    ResearchOpen Access
    Nature
    Volume: 626, P: 357-366

  • The authors present a protocol for the generation of human blastoids—structures morphologically and transcriptionally resembling complete blastocysts—from pluripotent stem cells and for their use in modeling implantation into hormonally stimulated endometrial cells.

    • Heidar Heidari Khoei
    • Alok Javali
    • Nicolas Rivron
    Protocols
    Nature Protocols
    Volume: 18, P: 1584-1620

  • Pluripotent stem cells are being used to generate models of early embryogenesis that are promising for discovery and translational research. To be useful, these models require critical consideration of their level of efficiency and fidelity to natural embryos. Here we propose criteria with which to raise the standards of stem-cell-based embryo models of human embryogenesis.

    • Alfonso Martinez Arias
    • Nicolas Rivron
    • Aryeh Warmflash
    Comments & Opinion
    Nature Cell Biology
    Volume: 26, P: 1625-1628