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Putting mammalian early embryonic cells into dormancy

The authors provide a suite of in vitro protocols through which mouse and human pluripotent stem cells, mouse blastocysts and human blastoids can be reversibly induced to enter a diapause-like dormant state via pharmacological inhibition of mTOR

Dhanur P. Iyer
Heidar Heidari Khoei
Aydan Bulut-Karslioglu
Protocols26 Jan 2026
Nature Protocols

P: 1-28
Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae

Teichoic acid is bound to peptidoglycan (wall teichoic acid, WTA) or to membrane glycolipids (lipoteichoic acid, LTA) in most Gram-positive bacteria. Here, the authors identify a putative ligase required for the assembly of LTA, but not WTA, and important for Streptococcus pneumoniae virulence in mouse models.

Nathalie Heß
Franziska Waldow
Nicolas Gisch
ResearchOpen Access12 Dec 2017
Nature Communications

Volume: 8, P: 1-13
To which world regions does the valence–dominance model of social perception apply?

Jones et al. examine the generalizability of the valence–dominance model of social judgements of faces in 41 countries across 11 world regions. They find evidence of both generalizability and variation, depending on the analytical method.

Benedict C. Jones
Lisa M. DeBruine
Nicholas A. Coles
Research04 Jan 2021
Nature Human Behaviour

Volume: 5, P: 159-169
Generating human blastoids modeling blastocyst-stage embryos and implantation

The authors present a protocol for the generation of human blastoids—structures morphologically and transcriptionally resembling complete blastocysts—from pluripotent stem cells and for their use in modeling implantation into hormonally stimulated endometrial cells.

Heidar Heidari Khoei
Alok Javali
Nicolas Rivron
Protocols15 Feb 2023
Nature Protocols

Volume: 18, P: 1584-1620
Precisely timed inhibition facilitates action potential firing for spatial coding in the auditory brainstem

Binaural cue processing in auditory brainstem relies on the precise temporal relationship between excitatory and inhibitory inputs. Here the authors provide direct evidence that sub-millisecond precise inhibition can tune sensitivity to input processing in the lateral superior olive via post inhibitory facilitation.

Barbara Beiderbeck
Michael H. Myoga
Michael Pecka
ResearchOpen Access02 May 2018
Nature Communications

Volume: 9, P: 1-13
A lectin S-domain receptor kinase mediates lipopolysaccharide sensing in Arabidopsis thaliana

Plants have a vast array of pattern-recognition receptor to detect microbial ligands, but how they sense lipopolysaccharide has remained unknown. Ranf et al. identify the receptor-like kinase SD1-29 as a de facto pattern-recognition receptor for lipopolysaccharide in Arabidopsis.

Stefanie Ranf
Nicolas Gisch
Dierk Scheel
Research02 Mar 2015
Nature Immunology

Volume: 16, P: 426-433
Cyclic electron flow compensates loss of PGDH3 and concomitant stromal NADH reduction

Moritz Krämer
Nicolás E. Blanco
Hans-Henning Kunz
ResearchOpen Access26 Nov 2024
Scientific Reports

Volume: 14, P: 1-13
Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1

Crystal and electron cryo-tomography structures of Mgm1 from Chaetomium thermophilum reveal that Mgm1 forms bent tetramers, which further assemble into helical filaments on both positively and negatively curved membranes.

Katja Faelber
Lea Dietrich
Oliver Daumke
Research10 Jul 2019
Nature

Volume: 571, P: 429-433
A distributable German clinical corpus containing cardiovascular clinical routine doctor’s letters

Phillip Richter-Pechanski
Philipp Wiesenbach
Nicolas A. Geis
ResearchOpen Access14 Apr 2023
Scientific Data

Volume: 10, P: 1-16
Global population genomic signature of Spodoptera frugiperda (fall armyworm) supports complex introduction events across the Old World

This population genomics study identifies the complex multiple introduction history of Spodoptera frugiperda (fall armyworm) from the Americas, into Africa and Asia. This provides new insight into the ‘east-to-west’ directionality of gene flow, and suggests ample genomic exchange at the nuclear level.

Wee Tek Tay
Rahul V. Rane
Karl H. J. Gordon
ResearchOpen Access07 Apr 2022
Communications Biology

Volume: 5, P: 1-15
Network integration and modelling of dynamic drug responses at multi-omics levels

Using a network propagation approach with integrated multi-omic data, Selevsek et al. develop a reproducible workflow for identifying drug toxicity effects in cellular systems. This is demonstrated with the analysis of anthracycline cardiotoxicity in cardiac microtissues under the effect of multiple drugs.

Nathalie Selevsek
Florian Caiment
Jos Kleinjans
ResearchOpen Access15 Oct 2020
Communications Biology

Volume: 3, P: 1-15
The Global Ambulatory Blood Pressure Monitoring (ABPM) in Heart Failure with Preserved Ejection Fraction (HFpEF) Registry. Rationale, design and objectives

Miguel Camafort-Babkowski
Akintunde Adeseye
Fernando Stuardo Wyss-Quintana
Research25 Nov 2020
Journal of Human Hypertension

Volume: 35, P: 1029-1037
Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized ¹³C magnetic resonance

Emine Can
Mor Mishkovsky
Arnaud Comment
ResearchOpen Access13 Jan 2020
Scientific Reports

Volume: 10, P: 1-8
Lipoteichoic acid of Streptococcus oralis Uo5: a novel biochemical structure comprising an unusual phosphorylcholine substitution pattern compared to Streptococcus pneumoniae

Nicolas Gisch
Dominik Schwudke
Dalia Denapaite
ResearchOpen Access18 Nov 2015
Scientific Reports

Volume: 5, P: 1-14
Definition and quantification of acute inflammatory white matter injury in the immature brain by MRI/MRS at high magnetic field

Gregory A. Lodygensky
Nicolas Kunz
Stéphane V. Sizonenko
Research17 Dec 2013
Pediatric Research

Volume: 75, P: 415-423
Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds

Marcha Verheijen
Ugis Sarkans
Alexandra Zerck
ResearchOpen Access14 Nov 2022
Scientific Data

Volume: 9, P: 1-11

Search

Putting mammalian early embryonic cells into dormancy

Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae

To which world regions does the valence–dominance model of social perception apply?

Generating human blastoids modeling blastocyst-stage embryos and implantation

Precisely timed inhibition facilitates action potential firing for spatial coding in the auditory brainstem

A lectin S-domain receptor kinase mediates lipopolysaccharide sensing in Arabidopsis thaliana

Cyclic electron flow compensates loss of PGDH3 and concomitant stromal NADH reduction

Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1

A distributable German clinical corpus containing cardiovascular clinical routine doctor’s letters

Global population genomic signature of Spodoptera frugiperda (fall armyworm) supports complex introduction events across the Old World

Network integration and modelling of dynamic drug responses at multi-omics levels

The Global Ambulatory Blood Pressure Monitoring (ABPM) in Heart Failure with Preserved Ejection Fraction (HFpEF) Registry. Rationale, design and objectives

Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized ¹³C magnetic resonance

Lipoteichoic acid of Streptococcus oralis Uo5: a novel biochemical structure comprising an unusual phosphorylcholine substitution pattern compared to Streptococcus pneumoniae

Definition and quantification of acute inflammatory white matter injury in the immature brain by MRI/MRS at high magnetic field

Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds

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