About 1.3 million total joint implants are placed annually, and around 80,000 patients develop implant failure due to periimplant fibrosis. Here, the authors show that inhibition of GREM1 in LEPR⁺ cells reduces peri-implant fibrosis and enhances per-implant osteogenesis, therefore represent a promising strategy to prevent and treat aseptic loosening.
- Vincentius Jeremy Suhardi
- Anastasia Oktarina
- Xu Yang
