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Showing 1–13 of 13 results
Advanced filters: Author: Nicolas X. Tritsch Clear advanced filters

  • In this work, fragments identified by 19F-NMR are optimized into submicromolar binders of the MITF transcription factor. These results support direct targeting of bHLH-LZ DNA binding domains and provide a foundation for the development of new melanoma therapies.

    • Deborah Castelletti
    • Jürgen Hinrichs
    • Wolfgang Jahnke
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-18

  • Liu and colleagues show that the vigor (that is, speed and amplitude) of dexterous movements is not controlled by ongoing fluctuations in extracellular dopamine within the dorsal striatum of mice.

    • Haixin Liu
    • Riccardo Melani
    • Nicolas X. Tritsch
    ResearchOpen Access
    Nature Neuroscience
    Volume: 28, P: 2432-2438

  • Dopamine release occurs in spatiotemporal waves. Here the authors propose that dopamine waves arise locally in the striatum, and provide evidence for striatal acetylcholine waves.

    • Lior Matityahu
    • Naomi Gilin
    • Joshua A. Goldberg
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-23

  • Reward signaling via dopamine is most commonly thought of as acting through neurons expressing either D1 or D2 dopamine receptors. Enriquez-Traba et al. show that neurons in the ventral striatum co-express D1 and D3 receptors, which they use to signal dissociable aspects of reward.

    • Nicolas X. Tritsch
    News & Views
    Nature Neuroscience
    Volume: 28, P: 6-7

  • Dopaminergic neurons in the ventral tegmental area have a role in modulating aggression in adult male mice, and this effect of dopamine depends strongly on fighting experience.

    • Bing Dai
    • Bingqin Zheng
    • Dayu Lin
    Research
    Nature
    Volume: 639, P: 430-437

  • It is self-evident that consuming alcohol affects brain function and behaviour. What is not clear, however, is how alcohol does so. A new study shows that impairments in balance and motor coordination evoked by low-dose alcohol are mediated not by ethanol itself but by one of its metabolites, which is produced locally by astrocytes in the brain rather than in the liver.

    • Riccardo Melani
    • Nicolas X. Tritsch
    News & Views
    Nature Metabolism
    Volume: 3, P: 293-294

  • Yamaguchi et al. identify a little-known amygdalar region, the posterior amygdala, as a key node in male mouse social behaviors. Two largely non-overlapping subpopulations in the posterior amygdala form parallel projections to distinct hypothalamic regions to regulate mating and fighting.

    • Takashi Yamaguchi
    • Dongyu Wei
    • Dayu Lin
    Research
    Nature Neuroscience
    Volume: 23, P: 1111-1124

  • The long-held doctrine that an individual neuron releases only one type of small molecule neurotransmitter has been challenged in recent years. In this Progress article, Sabatini and colleagues discuss recent evidence suggesting that co-release of GABA occurs in several neuronal populations in the adult mammalian CNS and the implications of such co-release for neuronal signalling.

    • Nicolas X. Tritsch
    • Adam J. Granger
    • Bernardo L. Sabatini
    Reviews
    Nature Reviews Neuroscience
    Volume: 17, P: 139-145

  • Acoustic information is detected by inner hair cells in mammalian cochlea and is transmitted to the brain via the auditory nerve. But auditory nerve activity is evident before the cochlear machinery develops the ability to process information. The mechanism that underlies this effect has been uncovered in a series of experiments, showing that supporting cells located in Kölliker's organ spontaneously release ATP, activating inner hair cells and thus auditory nerve fibres.

    • Nicolas X. Tritsch
    • Eunyoung Yi
    • Dwight E. Bergles
    Research
    Nature
    Volume: 450, P: 50-55

  • Activation of midbrain dopamine neurons rapidly inhibits action potential firing in both direct- and indirect-pathway striatal projection neurons through VMAT2-dependent vesicular release of the inhibitory transmitter GABA (γ-aminobutyric acid).

    • Nicolas X. Tritsch
    • Jun B. Ding
    • Bernardo L. Sabatini
    Research
    Nature
    Volume: 490, P: 262-266