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Showing 1–5 of 5 results
Advanced filters: Author: Nicoletta I. Petridou Clear advanced filters

  • Orientation of the mitotic spindle is influenced by extracellular forces acting on the cell cortex. Here Petridou et al.identify FAK as a key transducer of mechanical forces in this context and as a result is a key regulator of spindle orientation controlling tissue architecture and morphogenesis.

    • Nicoletta I. Petridou
    • Paris A. Skourides
    Research
    Nature Communications
    Volume: 5, P: 1-16

  • During cell division, the orientation of the mitotic spindle is sensitive to forces exerted on the cell cortex. Here Petridou and Skourides show that such cues are sensed by a mechanosensory complex established on force activated integrin β1 independent of ligand binding.

    • Nicoletta I. Petridou
    • Paris A. Skourides
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15

  • In each cell division during early embryogenesis, daughter cells acquire half the size of the mother cell. A study now reports that cytoplasmic flows sensing the cell boundaries allow daughter cells to adapt to their new size and reform their nuclear envelope in the right position.

    • Nicoletta I. Petridou
    News & Views
    Nature Cell Biology
    Volume: 27, P: 176-177

  • In this Review, we will discuss how the interplay and feedback between mechanical and biochemical signals control tissue morphogenesis and cell fate specification in embryonic development.

    • Nicoletta I. Petridou
    • Zoltán Spiró
    • Carl-Philipp Heisenberg
    Reviews
    Nature Cell Biology
    Volume: 19, P: 581-588